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Isotope productsDeuterium Labeled Compounds
Deuterium (Hydrogen-2) labeled compounds are chemical compounds in which one or more hydrogen atoms are replaced by deuterium, a stable isotope of hydrogen. Deuterium has one proton and one neutron in its nucleus, whereas the most common hydrogen isotope (protium) has only a single proton. Deuterium (Hydrogen-2) labeled compounds can be utilized in studying drug metabolism and reaction kinetics.
JNJ-6204
JNJ6204, JNJ 6204
T695222765264-50-2In house
JNJ-6204 is a deuterated compound that efficiently inhibits CSNK1D and CSNK1E.
- $195
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VX-984
M9831
T110671476074-39-1
VX-984 is an oral, selective DNA-PK inhibitor that can cross the blood-brain barrier. VX-984 inhibited the conjugation of non-homologous terminal NHEJ and acted on DSBs to break DNA double strand. VX-984 is commonly seen in glioblastoma (GBM) and non-small cell lung cancer (NSC-LC) studies.
- $126
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Fulvestrant-D3
ZM182780-d3, ZM 182780-d3, ZD9238-d3, ZD 9238-d3, ICI182780-d3, ICI 182780-d3
TMIJ-0244
Fulvestrant-D3 is a isotope labeled compound of Fulvestrant (T2146). Fulvestrant (ZM 182780) is an estrogen receptor (ER) antagonist and GPR30 agonist that inhibits cell proliferation and induces apoptosis and autophagy.
- $773
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Vitamin B3-D4
Nicotinic acid-d4, Nicotinic acid-(ring-d4)
T8530866148-15-0
Vitamin B3-D4 is the deuterium substitute for Niacin and is used to track Niacin metabolism in the body.
- $73
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Palbociclib-D8
PD0332991 D8, PD 0332991 D8, Palbociclib D8
T123551628752-83-9
Palbociclib-D8 is the 2H-labeled form of Palbociclib. Palbociclib (T1785) is an orally active CDK inhibitor that inhibits CDK4 and CDK6 (IC50=11/16 nM). Palbociclib (T1785) has anti-tumor activity and is used in research for estrogen receptor-positive and HER2-negative breast cancer.
- $489
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Donafenib
Sorafenib-d3, Sorafenib (D3), Bay 43-9006 (D3)
T169091130115-44-4
Donafenib is a deuterium-labeled Sorafenib (T0093L) which is a multikinase inhibitor (IC50s: 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively).
- $84
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Aniline-D5
TMIJ-03424165-61-1
Aniline-D5 is a deuterated isotope marker of Aniline (T207053), which can be used for isotope tracing.Aniline induces toxicity to the spleen through iron overload and oxidative stress via heme oxygenase 1 up-regulation and is able to lead to a significant increase in p-IKKα and p-IKKβ, which in turn increases NF-κB and AP-1 binding activity.
- $31
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5'-Deoxy-5'-methylthioadenosine-D3
5'-S-Methyl-5'-thioadenosine-d3, 5'-Methylthioadenosine-d3, 5'-Deoxy-5'-(methylthio)adenosine-d3, 5'-(Methylthio)-5'-deoxyadenosine-d3
TMID-0168174838-38-1
5'-Deoxy-5'-methylthioadenosine-D3 is a stable, deuterium-labeled analogue of the endogenous nucleoside metabolite 5'-Deoxy-5'-methylthioadenosine (T8227) (MTA, CAS 2457-80-9). this compound retains the tumor cell proliferation inhibitory effects of the parent molecule and is primarily utilized as an internal standard in mass spectrometry-based metabolomic studies to quantify MTA levels in biological samples.
- $249
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Melatonin-D4
N-Acetyl-5-methoxytryptamine D5, Melatonin D5
T1199566521-38-8
Melatonin-D4 is a hormone produced by the pineal gland, known for its role as a selective ATF-6 inhibitor that promotes apoptosis in human hepatoma cells via COX-2 downregulation. Additionally, it activates melatonin receptors and exhibits antioxidative and anti-inflammatory properties.
- $246
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DL-Metanephrine-D3 hydrochloride
TMIH-01971085333-94-3
DL-Metanephrine-D3 hydrochloride is L-Metanephrine labeled with deuterium atoms and can be used to study the metabolic flow of L-Metanephrine in the body.
- $198
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Isoniazid-D4
Isonicotinic hydrazide-d4, Isonicotinic acid hydrazide-d4, INH-d4
TMIJ-0309774596-24-6
Isoniazid-D4 is a deuterium isotope marker for Isoniazid (TMSM-1385), which can be used for isotope tracing and drug metabolism studies.Isoniazid is a prodrug that must be activated by the bacterial peroxidase KatG, and is bactericidal against rapidly dividing Mycobacterium species.
- $330
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5-Hydroxy-L-tryptophan-4,6,7-D3
Oxitriptan-d3, L-5-Hydroxytryptophan-d3, L-5-HTP-d3
TMID-01511276197-29-5
5-Hydroxy-L-tryptophan-4,6,7-D3 is L-5-Hydroxytryptophan labeled with 2H. L-5-Hydroxytryptophan (L-5-HTP) is a dietary supplement and a precursor to serotonin, which inhibits the IFN-γ induced PD-L1 expression. It promotes anti-tumor immunity and is used in research on migraine and depression.
- $123
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Corticosterone-D8
TMIH-01671271728-07-4
Corticosterone-D8 is a 2H-labeled corticosteroid, an orally active adrenal corticosteroid with mineralocorticoid and glucocorticoid activity, involved in hormonal regulation in animals.
- $129
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Ursodeoxycholic Acid-D4
Ursodeoxycholic acid-2,2,4,4-d4
TMIH-0590347841-46-7
Ursodeoxycholic Acid-D4 is the deuterium substitute of Ursodeoxycholic acid, and is an internal standard for the quantitative determination of Ursodeoxycholic Acid (T0700) (UDCA) levels by LC/MS or GC/MS.
- $105
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L-Kynurenine-D4
TMID-00712672568-86-2
L-Kynurenine-D4 is a deuterated compound of L-Kynurenine, suitable for isotope tracing. L-Kynurenine (T4928) is a metabolite of tryptophan and an endogenous agonist of the AHR.
- $265
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L-838417-D9
CTP-354, CTP354, C-21191
T223011213669-91-0
L-838417-D9 is a novel deuterated subtype-selective GABAA positive allosteric modulator, acting as a partial agonist at α2, α3 and α5 subtypes[1].
- $30
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Sulfamethoxazole-D4
Ro4-2130 D4, Ro 4-2130 D4, Ro 42130 D4
T130311020719-86-1
Sulfamethoxazole-D4 is a deuterium labeled Sulfamethoxazole (TMSM-2154), which can be used for isotope tracing. Sulfamethoxazole is a sulfonamide antimicrobial agent.
- $249
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Ketorolac-D5
Ketorolac D5
T117541215767-66-0
Ketorolac-D5 is a deuterated compound of ketorolac for isotope tracing. Ketorolac (T21412) is a non-steroidal anti-inflammatory agent and inhibitor of both COX-1 and COX-2.
- $149
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L-Carnitine-D3 Chloride
L-Carnitine-d3 hydrochloride, (R)-Carnitine-d3 hydrochloride
TMIH-0296350818-62-1
L-Carnitine-D3 Chloride is the deuterated form of L-Carnitine Chloride (TMIM-00025), used as an internal standard for detecting total carnitine in raw materials. L-Carnitine (L (-)-Carnitine) is an endogenous human molecule involved in fatty acid metabolism.
- $33
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Vanillin-D3
p-Vanillin-d3, 4-Hydroxy-3-methoxybenzaldehyde-d3
TMIH-059374495-74-2
Vanillin-D3 is the deuterium marker for vanillin and can be used for isotopic tracing. Vanillin (T6717) (Zimco) is a natural product extracted from vanilla beans and is commonly used in perfumes, food and pharmaceuticals.
- $64
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Choline-D4 Chloride
Choline-1,1,2,2-D4 Chloride
TMIH-0149285979-70-6
Choline-D4 Chloride is a deuterated form of Choline Chloride (TMSM-3273), an essential nutrient activating α7 nicotinic receptors with anti-inflammatory and analgesic activity. It impacts atherosclerosis, neurological diseases, and liver diseases.
- $40
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Dimethyl-D6 Sulfoxide
T92422206-27-1
Dimethyl-D6 Sulfoxide is a form in which hydrogen ("H") of dimethyl sulfoxide (TMSM-4368) ( (CH3) 2S = O) is replaced by another isotope deuterium ("d"). Dimethyl-D6 Sulfoxide is a common solvent in nuclear magnetic resonance spectroscopy.
- $35
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Nicotinamide-D4
Nicotinic acid amide-d4, Niacinamide-d4
T69395347841-88-7
Nicotinamide-D4 is a deuterium-labelled compound of Nicotinamide (TMSM-1731) for isotope tracing. Nicotinamide, a vitamin B3 derivative, inhibits SIRT1 and SIRT2.
- $40
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Zanubrutinib-D5
BGB3111-d5, BGB-3111-d5
TMIH-0610
Zanubrutinib-D5, a deuterium-labeled Zanubrutinib (T7584), is an orally available Bruton's tyrosine kinase inhibitor for the study of B-cell malignancies.
- $514
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