N-PEG3-N'-(azide-PEG3)-Cy5

Name: N-PEG3-N'-(azide-PEG3)-Cy5
Brand: TargetMol
SKU: T18460
Rating: 4.5 (1 reviews)

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Catalog No. T18460Cas No. 2226235-96-5

N-PEG3-N'-(azide-PEG3)-Cy5 (chloride) is a polyethylene glycol (PEG) derivative functioning as a PROTAC linker, essential for synthesizing proteolysis targeting chimeras (PROTACs)[1].

N-PEG3-N'-(azide-PEG3)-Cy5

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Catalog No. T18460Cas No. 2226235-96-5

N-PEG3-N'-(azide-PEG3)-Cy5 (chloride) is a polyethylene glycol (PEG) derivative functioning as a PROTAC linker, essential for synthesizing proteolysis targeting chimeras (PROTACs)[1].

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Product Introduction

Bioactivity

Description	N-PEG3-N'-(azide-PEG3)-Cy5 (chloride) is a polyethylene glycol (PEG) derivative functioning as a PROTAC linker, essential for synthesizing proteolysis targeting chimeras (PROTACs)[1].
In vitro	PROTACs consist of two distinct ligands connected by a linker: one binds to an E3 ubiquitin ligase, while the other targets a specific protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Chemical Properties

Molecular Weight	724.33
Formula	C₃₉H₅₄ClN₅O₆
Cas No.	2226235-96-5
Smiles	[Cl-].[N-]=[N+]=NCCOCCOCCOCCN1C=2C=CC=CC2C(C1=CC=CC=CC3=[N+](C=4C=CC=CC4C3(C)C)CCOCCOCCO)(C)C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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