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TMP-778

Name: TMP-778
Brand: TargetMol
SKU: T13172L1
Price: 223 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T13172L1Cas No. 1422171-08-1

TMP-778 is a selective inverse agonist of RORγt.

TMP-778

😃Good

Purity: 99.68%

Catalog No. T13172L1Cas No. 1422171-08-1

TMP-778 is a selective inverse agonist of RORγt.

Pack Size	Price	Availability
1 mg	$223	In Stock
5 mg	$617	In Stock
50 mg	$1,850	Backorder
1 mL x 10 mM (in DMSO)	$732	In Stock

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Batch Information

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Purity:99.68%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description

TMP-778 is a selective inverse agonist of RORγt.

Chemical Properties

Molecular Weight	494.58
Formula	C₃₁H₃₀N₂O₄
Cas No.	1422171-08-1
Smiles	[C@@H](NC(CC=1C=C2C(=CC1)OC(C(O)C=3C(C)=NOC3C)=C2)=O)(C4=C(C)C=C(C)C=C4)C5=CC=CC=C5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (111.21 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0219 mL	10.1096 mL	20.2192 mL	101.0959 mL
5 mM	0.4044 mL	2.0219 mL	4.0438 mL	20.2192 mL
10 mM	0.2022 mL	1.0110 mL	2.0219 mL	10.1096 mL
20 mM	0.1011 mL	0.5055 mL	1.0110 mL	5.0548 mL
50 mM	0.0404 mL	0.2022 mL	0.4044 mL	2.0219 mL
100 mM	0.0202 mL	0.1011 mL	0.2022 mL	1.0110 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc