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Aβ aggregation-IN-5
Catalog No. T214890 Copy Product Info
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Aβ aggregation-IN-5 is an inhibitor of β-amyloid (amyloid-β) aggregation that can penetrate the blood-brain barrier. It prevents Aβ aggregation/oligomerization, rescues cells damaged by Aβ/ROS toxicity, and reduces microglial activation and nitric oxide (NO) production. In APP/PSEN1 mouse models, Aβ aggregation-IN-5 decreases amyloid burden, neuroinflammation, and microglial activation. This compound is used in Alzheimer's disease research.
Aβ aggregation-IN-5
Copy Product Info🥰Excellent
Catalog No. T214890
Aβ aggregation-IN-5 is an inhibitor of β-amyloid (amyloid-β) aggregation that can penetrate the blood-brain barrier. It prevents Aβ aggregation/oligomerization, rescues cells damaged by Aβ/ROS toxicity, and reduces microglial activation and nitric oxide (NO) production. In APP/PSEN1 mouse models, Aβ aggregation-IN-5 decreases amyloid burden, neuroinflammation, and microglial activation. This compound is used in Alzheimer's disease research.
Aβ aggregation-IN-5
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Aβ aggregation-IN-5 is an inhibitor of β-amyloid (amyloid-β) aggregation that can penetrate the blood-brain barrier. It prevents Aβ aggregation/oligomerization, rescues cells damaged by Aβ/ROS toxicity, and reduces microglial activation and nitric oxide (NO) production. In APP/PSEN1 mouse models, Aβ aggregation-IN-5 decreases amyloid burden, neuroinflammation, and microglial activation. This compound is used in Alzheimer's disease research. |
| In vitro | Aβ aggregation-IN-5 (Compound P4B), at a concentration of 20 µM for 24–48 hours, inhibits the aggregation/oligomerization of Aβ (10 µM). At concentrations of 10–20 μM for 24–30 hours, it reduces Aβ and ROS-induced cytotoxicity in SH-SY5Y cells. Furthermore, Aβ aggregation-IN-5 (10 µM; 24 hours) decreases microglial activation and nitric oxide (NO) production in N9 cells. |
| In vivo | Aβ aggregation-IN-5 is administered at 5 mg/kg via intraperitoneal injection daily over a period of 60 days. This treatment reduces Aβ deposition and inflammatory response in aged APP/PSEN1 mouse models. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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