TNG961

Name: TNG961
Brand: TargetMol
SKU: T217526
Rating: 4.5 (1 reviews)

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TNG961 is an orally active, selective molecular chaperone degrader that interferes with the PELO/HBS1L-mediated ribosomal rescue process by inducing an interaction between Cereblon (CRBN) and HBS1L, thereby selectively promoting the ubiquitination and proteasomal degradation of HBS1L.

Pack Size	Price	USA Stock	Global Stock
1 mg	$196	8-10 weeks	8-10 weeks
5 mg	$448	8-10 weeks	8-10 weeks
25 mg	$987	8-10 weeks	8-10 weeks
100 mg	$2,280	8-10 weeks	8-10 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	TNG961 is an orally active, selective molecular chaperone degrader that interferes with the PELO/HBS1L-mediated ribosomal rescue process by inducing an interaction between Cereblon (CRBN) and HBS1L, thereby selectively promoting the ubiquitination and proteasomal degradation of HBS1L.
In vitro	TNG961 causes a decrease in HBS1L protein levels and disrupts PELO, which is involved in ribosome rescue, while having no effect on SALL4 protein levels [1]. Both TNG961-induced HBS1L degradation and PELO instability can be reversed by CRBN inactivation, confirming its mechanism of action [1]. TNG961 (4 h) induces maximal HBS1L degradation in genetically engineered HiBiT knock-in cells without affecting GSPT1 protein levels [1].
In vivo	In an xenograft model of FOCAD deficiency, TNG961 (oral) downregulates HBS1L in a dose-dependent manner and induces instability in the PELO protein, thereby causing tumor arrest or regression in multiple lineages [1].

Chemical Properties

Molecular Weight	539.57
Formula	C₂₈H₂₄F₃N₃O₃S
Smiles	O=C(N1)CC[C@H](C2=CC3=C(C(NC(NC(C)(C)C4=CC(C=CC(C(F)(F)F)=C5)=C5S4)=O)=CC=C3)C=C2)C1=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc