TNG961

Name: TNG961
Brand: TargetMol
SKU: T217526
Rating: 4.5 (1 reviews)

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TNG961 is a potent, highly selective, CRBN-dependent HBS1L (GSPT3) molecular chaperone inhibitor. By degrading HBS1L, TNG961 specifically disrupts protein homeostasis in FOCAD-deficient cancer cells, thereby inducing growth inhibition and cell death. TNG961 can be used in studies of FOCAD-deficient tumors.

Pack Size	Price	USA Stock	Global Stock
1 mg	$196	8-10 weeks	8-10 weeks
5 mg	$448	8-10 weeks	8-10 weeks
25 mg	$987	8-10 weeks	8-10 weeks
100 mg	$2,280	8-10 weeks	8-10 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	TNG961 is a potent, highly selective, CRBN-dependent HBS1L (GSPT3) molecular chaperone inhibitor. By degrading HBS1L, TNG961 specifically disrupts protein homeostasis in FOCAD-deficient cancer cells, thereby inducing growth inhibition and cell death. TNG961 can be used in studies of FOCAD-deficient tumors.
In vitro	TNG961 selectively kills FOCAD-deficient cancer cells, inducing translational stalling, endoplasmic reticulum stress, and activation of the unfolded protein response. [1] In vitro experiments indicate that TNG961 causes a dose-dependent decrease in HBS1L protein levels, thereby disrupting the PELO domain involved in ribosomal rescue. TNG961 exhibits pan-proteomic selectivity for HBS1L; Western blot analysis shows no change in SALL4 protein levels.[2]
In vivo	Oral administration of TNG961 induces dose-dependent regression of FOCAD-deficient tumors and retains potent activity against FOCAD-deficient tumors resistant to PRMT5 inhibitors. [1] In a FOCAD-deficient xenograft model, TNG961 (oral) dose-dependently degrades HBS1L and induces PELO protein instability, leading to tumor arrest or regression across multiple lineages.[2]

Chemical Properties

Molecular Weight	539.57
Formula	C₂₈H₂₄F₃N₃O₃S
Smiles	O=C([C@H](CC1)C2=CC3=CC=CC(NC(NC(C)(C)C4=CC5=C(C=C(C(F)(F)F)C=C5)S4)=O)=C3C=C2)NC1=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.