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Methysticin

Name: Methysticin
Brand: TargetMol
SKU: TQ0276
Rating: 4.5 (1 reviews)

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Catalog No. TQ0276Cas No. 20697-20-5

Alias DL-Methysticin, (±)-Methystici

Methysticin, a major kavalactone extracted from kava, can induce CYP1A1.

Methysticin

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Catalog No. TQ0276Alias DL-Methysticin, (±)-MethysticiCas No. 20697-20-5

Methysticin, a major kavalactone extracted from kava, can induce CYP1A1.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$698	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Methysticin, a major kavalactone extracted from kava, can induce CYP1A1.
In vivo	Methysticin (6 mg/kg) is administered orally once weekly for six months to 6-month-old transgenic APP/Psen1 mice. This treatment initiates activation of the Nrf2 pathway in the mice's hippocampus and cortex. Despite Methysticin not altering Aβ deposition in the brains of treated APP/Psen1 mice compared to controls, it significantly mitigates microgliosis, astrogliosis, and the secretion of pro-inflammatory cytokines TNF-α and IL-17A. Additionally, Methysticin markedly activates the Nrf2/ARE pathway specifically in the hippocampus and cortex, but not in the midbrain and cerebellum of ARE-luciferase reporter gene mice, leading to a significant increase in the expression of both genes relative to untreated animals.
Synonyms	DL-Methysticin, (±)-Methystici

Chemical Properties

Molecular Weight	274.27
Formula	C₁₅H₁₄O₅
Cas No.	20697-20-5
Smiles	C(=C/C1CC(OC)=CC(=O)O1)\C=2C=C3C(=CC2)OCO3
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 1 mg/mL (3.65 mM), Sonication is recommended.

DMSO: 5 mg/mL (18.23 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6460 mL	18.2302 mL	36.4604 mL	182.3021 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.7292 mL	3.6460 mL	7.2921 mL	36.4604 mL
10 mM	0.3646 mL	1.8230 mL	3.6460 mL	18.2302 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc