CD131 Protein, Human, Recombinant (His)

Name: CD131 Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPY-01650
Price: 70 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: SMDP5, IL5RB, IL3RB, colony stimulating factor 2 receptor, β, low-affinity (granulocyte-macrophage), colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage), CDw131, CD131) Copy Product Info

Synonyms: SMDP5, IL5RB, IL3RB, colony stimulating factor 2 receptor, β, low-affinity (granulocyte-macrophage), colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage), CDw131, CD131

Catalog No. TMPY-01650 Copy Product Info

Purity: 97.8%

CD131 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50 kDa and the accession number is P32927-1.

Pack Size	Price	USA Stock	Global Stock
5 µg	$70	-	In Stock
10 µg	$109	-	In Stock
20 µg	$182	-	In Stock
50 µg	$357	-	In Stock
100 µg	$600	-	In Stock
200 µg	$1,050	7-10 days	7-10 days
500 µg	$2,190	7-10 days	7-10 days
1 mg	$3,910	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:97.8%

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Measured by its binding ability in a functional ELISA. Immobilized human CD131 at 10 μg/ml (100 μl/well) can bind human Fc-GMCSF, The EC50 of human Fc-GMCSF is 250-500 ng/ml.
Description	CD131 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50 kDa and the accession number is P32927-1.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	P32927-1
Construction	A DNA sequence encoding the extracellular domain (Met 1-Trp 443) of human CSF2RB (NP_000386.1) expressed, fused with a polyhistidine-tag at the C-terminus. Predicted N terminal: Trp 17
Protein Purity	> 97 % as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonyms	SMDP5, IL5RB, IL3RB, colony stimulating factor 2 receptor, β, low-affinity (granulocyte-macrophage), colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage), CDw131, CD131
Research Background	Colony stimulating factor 2 receptor, beta, low-affinity (CSF2RB) also known as CD131 antigen (CD131), cytokine receptor common subunit beta, GM-CSF/IL-3/IL-5 receptor common beta-chain, interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (IL3RB), is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this protein have been reported to be associated with protein alveolar proteinosis (PAP). CD131 belongs to the type I cytokine receptor family. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Defects in CD131/CSF2RB are the cause of pulmonary surfactant metabolism dysfunction type 5 (SMDP5). SMDP5 is a rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.

Chemical Properties

Molecular Weight

50 kDa (predicted); 50-55 kDa (reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.