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Hydrocortisone aceponate

Name: Hydrocortisone aceponate
Brand: TargetMol
SKU: T32114
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T32114Cas No. 74050-20-7

Alias Suniderma, Hydrocortisone 17-propionate 21-acetate, Efficort

Hydrocortisone aceponate (Hydrocortisone 17-propionate 21-acetate) is an effective topical glucocorticoid cream used to treat various skin diseases.

Hydrocortisone aceponate

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Purity: 98.12%

Catalog No. T32114Alias Suniderma, Hydrocortisone 17-propionate 21-acetate, EfficortCas No. 74050-20-7

Hydrocortisone aceponate (Hydrocortisone 17-propionate 21-acetate) is an effective topical glucocorticoid cream used to treat various skin diseases.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$33	In Stock	In Stock
25 mg	$58	In Stock	In Stock
50 mg	$95	In Stock	In Stock
100 mg	$142	In Stock	In Stock
200 mg	$198	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.12%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Hydrocortisone aceponate AI Summary

Hydrocortisone aceponate shows a moderate binding affinity towards a variety of human receptors and enzymes, including DRD1, KCNH2, SLC6A3, ESR1, ACHE, SLC6A2, SLC6A4, ADRA2A, OPRM1, DRD3, CHRM2, HTR1A, TBXA2R, ADORA3, HRH3, GABRA1, AR, PGR, PTGS1, and PDE4A. It has agonist activities targeting HTR2B, ADRA1A, CHRM1, and TBXA2R. However, the compound only exhibited notable inhibition or binding affinity at higher concentrations for some targets, showing an AC50 value of 19309.9 nM for CHRM1 (as an antagonist), and 314.4 nM and 326.1 nM for AR and PGR respectively. The compound did not show significant inhibitory activity against most targets at tested concentrations over 30000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Hydrocortisone aceponate (Hydrocortisone 17-propionate 21-acetate) is an effective topical glucocorticoid cream used to treat various skin diseases.
Targets&IC50	IL-6:6.7 μM
Synonyms	Suniderma, Hydrocortisone 17-propionate 21-acetate, Efficort

Chemical Properties

Molecular Weight	460.56
Formula	C₂₆H₃₆O₇
Cas No.	74050-20-7
Smiles	[H][C@@]12CC[C@](OC(=O)CC)(C(=O)COC(C)=O)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
Relative Density.	1.23g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (195.41 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (10.86 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1713 mL	10.8563 mL	21.7127 mL	108.5635 mL
5 mM	0.4343 mL	2.1713 mL	4.3425 mL	21.7127 mL
10 mM	0.2171 mL	1.0856 mL	2.1713 mL	10.8563 mL
20 mM	0.1086 mL	0.5428 mL	1.0856 mL	5.4282 mL
50 mM	0.0434 mL	0.2171 mL	0.4343 mL	2.1713 mL
100 mM	0.0217 mL	0.1086 mL	0.2171 mL	1.0856 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc