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Anatibant 2HCl

Name: Anatibant 2HCl
Brand: TargetMol
SKU: T26627L
Price: 347 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T26627LCas No. 209788-45-4

Alias Anatibant 2HCl(209733-45-9 Free base)

Anatibant 2HCl is a small molecule bradykinin B2 receptor antagonist for the treatment of neurological disorders and may be used in the study of brain injury.

Anatibant 2HCl

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Purity: 99.2%

Catalog No. T26627LAlias Anatibant 2HCl(209733-45-9 Free base)Cas No. 209788-45-4

Anatibant 2HCl is a small molecule bradykinin B2 receptor antagonist for the treatment of neurological disorders and may be used in the study of brain injury.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$347	In Stock	In Stock
5 mg	$823	In Stock	In Stock
10 mg	$1,090	In Stock	In Stock
25 mg	$1,590	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.2%

ee:100%

Appearance:Solid

Color:White to Yellow

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COA CSFC FNMR HNMR IC ORP LCMS

Product Introduction

Bioactivity

Description	Anatibant 2HCl is a small molecule bradykinin B2 receptor antagonist for the treatment of neurological disorders and may be used in the study of brain injury.
Targets&IC50	Bradykinin receptor B2:1.74 nM (Ki, rat recombinant B2 receptor), Bradykinin receptor B2:0.67 nM (Ki, human recombinant B2 receptor), Bradykinin receptor B2:1.37 nM (Ki, guinea-pig recombinant B2 receptor)
In vivo	Anatibant (3.0 mg/kg b.w.; Subcutaneous Injection; Male C57/Bl6 mice (CCI)) was administrated as a subcutaneous bolus 15 min and 8h after TBI. ICP was measured 3, 6, and 10 h after injury, and contusion volume was quantified 24 h after trauma. Our data demonstrate a significant reduction of ICP (16.6+/-1.67 mmHg vs. 24.40+/-3.58 mmHg; n=6; p=0.002) and of contusion volume 24 h after trauma (28.28+/-5.18 mm3 vs. 35.0+/-3.32 mm3 n=7; p=0.003) in treated mice. Therefore we conclude, that inhibition of bradykinin B2 receptors seems to be a promising treatment option, and might therefore be investigated in clinical trials for the treatment of TBI.[1]
Synonyms	Anatibant 2HCl(209733-45-9 Free base)

Chemical Properties

Molecular Weight	784.58
Formula	C₃₄H₃₆Cl₂N₆O₅S.2ClH
Cas No.	209788-45-4
Smiles	ClC(C(S(=O)(N1[C@@H](CCC1)C(NCCCNC(C2=CC=C(C=C2)C(N)=N)=O)=O)=O)=CC=C3Cl)=C3COC4=CC=CC5=C4N=C(C)C=C5C.Cl.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (70.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2746 mL	6.3728 mL	12.7457 mL	63.7284 mL
5 mM	0.2549 mL	1.2746 mL	2.5491 mL	12.7457 mL
10 mM	0.1275 mL	0.6373 mL	1.2746 mL	6.3728 mL
20 mM	0.0637 mL	0.3186 mL	0.6373 mL	3.1864 mL
50 mM	0.0255 mL	0.1275 mL	0.2549 mL	1.2746 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc