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Apimostinel

Name: Apimostinel
Brand: TargetMol
SKU: T14306
Rating: 4.5 (1 reviews)

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Catalog No. T14306Cas No. 1421866-48-9

Alias NRX-1074, AGN-241660

Apimostinel (NRX-1074; AGN-241660) is a partial agonist of the NMDA receptor.

Apimostinel

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Catalog No. T14306Alias NRX-1074, AGN-241660Cas No. 1421866-48-9

Apimostinel (NRX-1074; AGN-241660) is a partial agonist of the NMDA receptor.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,490	6-8 weeks	6-8 weeks
50 mg	$1,940	6-8 weeks	6-8 weeks
100 mg	$2,800	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Apimostinel (NRX-1074; AGN-241660) is a partial agonist of the NMDA receptor.
In vitro	Apimostinel (NRX-1074) modulates the NMDA receptor similarly to GLYX-13 but includes a synthetic amino acid modification that enhances its potency and oral bioavailability[1].
In vivo	In preclinical models, both compounds demonstrate high efficacy in treating various CNS disorders[1].
Synonyms	NRX-1074, AGN-241660

Chemical Properties

Molecular Weight	503.59
Formula	C₂₅H₃₇N₅O₆
Cas No.	1421866-48-9
Smiles	C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@@]1(Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Relative Density.	1.330 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 155 mg/mL (307.79 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (9.93 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9857 mL	9.9287 mL	19.8574 mL	99.2871 mL
5 mM	0.3971 mL	1.9857 mL	3.9715 mL	19.8574 mL
10 mM	0.1986 mL	0.9929 mL	1.9857 mL	9.9287 mL
20 mM	0.0993 mL	0.4964 mL	0.9929 mL	4.9644 mL
50 mM	0.0397 mL	0.1986 mL	0.3971 mL	1.9857 mL
100 mM	0.0199 mL	0.0993 mL	0.1986 mL	0.9929 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc