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Daminozide

Name: Daminozide
Brand: TargetMol
SKU: T3719
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3719Cas No. 1596-84-5

Alias Succinic Acid, DMASA, Aminozide

Daminozide (Succinic Acid) is a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily.

Daminozide

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Purity: 99.88%

Catalog No. T3719Alias Succinic Acid, DMASA, AminozideCas No. 1596-84-5

Daminozide (Succinic Acid) is a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily.

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$42	In Stock	In Stock
1 g	$50	In Stock	In Stock
5 g	$79	-	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.88%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Daminozide AI Summary

Daminozide exhibits mixed type inhibition of human KDM2A, competitive inhibition with 2-oxoglutarate, and inhibits various other lysine demethylase enzymes including KDM3A, KDM4E, KDM5C, KDM6B, KDM7A, PHD2, FIH, BBOX1, and PHF8. It demonstrates moderate inhibition against KDM2A (IC50: 1500.0 nM) and potent inhibition against KDM7B (IC50: 550.0 nM), while showing lower activity against enzymes like KDM6A, KDM5A, KDM4C, and KDM4A. The compound also exhibits potent activity against Plasmodium falciparum strains, namely DD2 (0.7 nM), HB3 (167.7 nM), and 3D7 (1882.1 nM), and inhibits human Apurinic/apyrimidinic Endonuclease 1 (APE1) with a potency of 794.3 nM. Additionally, it shows antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity in both Caco-2 (inhibition rate of -4.94% at 10 µM) and VERO-6 cells (0.33% at 10 µM). It also inhibits SARS-CoV-2 3CL-Pro protease by 23.94% at 20 µM through FRET assay, and shows minor inhibition against human HDAC6 (-17.99% with a commercial substrate). However, it has weak or no inhibitory activity against Paramecium bursaria chlorella virus 1 CPH enzyme (IC50 > 100,000.0 nM). This broad inhibitory profile suggests potential for further pharmacological exploration..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Daminozide (Succinic Acid) is a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily.
Targets&IC50	PHF8:0.55 μM, KDM2A:1.5 μM
Synonyms	Succinic Acid, DMASA, Aminozide

Chemical Properties

Molecular Weight	160.17
Formula	C₆H₁₂N₂O₃
Cas No.	1596-84-5
Smiles	CN(C)NC(=O)CCC(O)=O
Relative Density.	1.183g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 18.33 mg/mL (114.44 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.49 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.2434 mL	31.2168 mL	62.4337 mL	312.1683 mL
5 mM	1.2487 mL	6.2434 mL	12.4867 mL	62.4337 mL
10 mM	0.6243 mL	3.1217 mL	6.2434 mL	31.2168 mL
20 mM	0.3122 mL	1.5608 mL	3.1217 mL	15.6084 mL
50 mM	0.1249 mL	0.6243 mL	1.2487 mL	6.2434 mL
100 mM	0.0624 mL	0.3122 mL	0.6243 mL	3.1217 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc