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PCO371

Name: PCO371
Brand: TargetMol
SKU: T16442
Price: 61 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: 2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-) Copy Product Info

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Synonyms: 2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-

Catalog No. T16442 Copy Product Info

Purity: 99.25%

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PCO371 belongs to small molecule agonists and is a full PTH1R (parathyroid hormone receptor 1) agonist with oral activity, cell permeability, and selectivity for PTH1R (no effect on PTH2R). This compound is used in research on PTH1R activation mechanisms and related signaling pathways.

Cas No. 1613373-33-3

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Pack Size	Price	USA Stock	Global Stock
1 mg	$61	In Stock	In Stock
5 mg	$147	In Stock	In Stock
10 mg	$218	In Stock	In Stock
25 mg	$396	In Stock	In Stock
50 mg	$562	-	In Stock
100 mg	$795	-	In Stock
1 mL x 10 mM (in DMSO)	$198	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.25%

Color:White

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	PCO371 belongs to small molecule agonists and is a full PTH1R (parathyroid hormone receptor 1) agonist with oral activity, cell permeability, and selectivity for PTH1R (no effect on PTH2R). This compound is used in research on PTH1R activation mechanisms and related signaling pathways.
Targets & IC50	LLC-PK1 cells:4.1 mM (EC50), PTHR1 (COS-7 cells):2.4 μM (EC50), hPTHR1-delNT (COS-7 cells):17 μM (EC50)
In vitro	Methods: The in vitro activity of PCO371 was validated using a cAMP accumulation assay in AD293 cells. Cells were incubated with various concentrations of PCO371 for 30 minutes. Results: PCO371 induced cAMP levels comparable to PTH, indicating that PCO371 is a full G protein agonist of PTH1R. Data were obtained from three independent experiments, each with three technical replicates, and normalized to the maximum response of PTH.[1]
Synonyms	2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-

Chemical Properties

Molecular Weight	635.65
Formula	C₂₉H₃₂F₃N₅O₆S
Cas No.	1613373-33-3
Smiles	Cc1cc(cc(C)c1CCS(=O)(=O)N1CCC2(CC1)N=C(NC2=O)c1ccc(OC(F)(F)F)cc1)N1C(=O)NC(=O)C1(C)C
Relative Density.	1.47 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Keep away from direct sunlight,Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (188.78 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (7.87 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5732 mL	7.8660 mL	15.7319 mL	78.6596 mL
5 mM	0.3146 mL	1.5732 mL	3.1464 mL	15.7319 mL
10 mM	0.1573 mL	0.7866 mL	1.5732 mL	7.8660 mL
20 mM	0.0787 mL	0.3933 mL	0.7866 mL	3.9330 mL
50 mM	0.0315 mL	0.1573 mL	0.3146 mL	1.5732 mL
100 mM	0.0157 mL	0.0787 mL	0.1573 mL	0.7866 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.