Siglec-3/CD33 Protein, Human, Recombinant, FITC conjugated

Name: Siglec-3/CD33 Protein, Human, Recombinant, FITC conjugated
Brand: TargetMol
SKU: TMPY-05571
Rating: 4.5 (1 reviews)

(Synonyms: Siglec-3, SIGLEC3, p67, CD33 molecule) Copy Product Info

Synonyms: Siglec-3, SIGLEC3, p67, CD33 molecule

Catalog No. TMPY-05571 Copy Product Info

Siglec-3/CD33 Protein, Human, Recombinant, FITC conjugated is expressed in HEK293 mammalian cells. The accession number is AAH28152.1.

Pack Size	Price	USA Stock	Global Stock
10 µg	$197	7-10 days	7-10 days
25 µg	$385	7-10 days	7-10 days
50 µg	$598	7-10 days	7-10 days
100 µg	$1,070	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Tested by Flow cytometric analysis of anti-CD33 CAR expression.
Description	Siglec-3/CD33 Protein, Human, Recombinant, FITC conjugated is expressed in HEK293 mammalian cells. The accession number is AAH28152.1.
Species	Human
Expression System	HEK293 Cells
Tag	Tag Free
Accession Number	AAH28152.1
Construction	Recombinant human CD33 (AAH28152.1, Met1-His259) are conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Formulation	Aqueous solution containing 0.5% BSA and 0.03% Proclin 300
Synonyms	Siglec-3, SIGLEC3, p67, CD33 molecule
Research Background	Myeloid cell surface antigen CD33 also known as Sialic acid binding Ig-like lectin 3, CD33 antigen or Siglec-3, is a member of the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. This Single-pass type I membrane protein contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. CD33 /Siglec-3 is a putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. CD33 /Siglec-3 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33/Siglec-3 induces apoptosis in acute myeloid leukemia (in vitro). CD33/Siglec-3 can function as a sialic acid-dependent cell adhesion molecule and that binding can be modulated by endogenous sialoglycoconjugates when CD33 is expressed in a plasma membrane.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

Storage & Solubility Information

Shipping	Proteins are shipped with blue ice.
Storage	This reagent is stable for 6 months when stored at 2°C-8°C. Protected from prolonged exposure to light. Do not freeze!