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YW2036

Name: YW2036
Brand: TargetMol
SKU: T67866
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T67866Cas No. 2131223-92-0

YW2036 is an inhibitor of Wnt signaling pathway.

YW2036

😃Good

Purity: 99.94%

Catalog No. T67866Cas No. 2131223-92-0

YW2036 is an inhibitor of Wnt signaling pathway.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$41	-	In Stock
5 mg	$103	-	In Stock
10 mg	$156	-	In Stock
25 mg	$248	-	In Stock
50 mg	$350	-	In Stock
100 mg	$470	-	In Stock
200 mg	$625	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly

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Batch Information

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Purity:99.94%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	YW2036 is an inhibitor of Wnt signaling pathway.
In vitro	The inhibitory potency of the synthesized compounds against the Wnt signaling pathway was determined using the Wnt-HEK293 luciferase gene reporter assay that was described previously. Compound YW2036 (1a) had an IC50 value of 2.2 nM[1].

Chemical Properties

Molecular Weight	328.37
Formula	C₂₀H₁₆N₄O
Cas No.	2131223-92-0
Smiles	CC=1N(N=CC1C(NC2=NC3=C(C=C2)C=CC=C3)=O)C4=CC=CC=C4
Relative Density.	1.25 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (137.04 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0453 mL	15.2267 mL	30.4535 mL	152.2673 mL
5 mM	0.6091 mL	3.0453 mL	6.0907 mL	30.4535 mL
10 mM	0.3045 mL	1.5227 mL	3.0453 mL	15.2267 mL
20 mM	0.1523 mL	0.7613 mL	1.5227 mL	7.6134 mL
50 mM	0.0609 mL	0.3045 mL	0.6091 mL	3.0453 mL
100 mM	0.0305 mL	0.1523 mL	0.3045 mL	1.5227 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc