CXCL13/BCA-1 Protein, Canine, Recombinant (His)

Catalog No. TMPY-03708

BCA-1 Protein, Canine, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 12.1 kDa and the accession number is XP_851619.3.

CXCL13/BCA-1 Protein, Canine, Recombinant (His)

Catalog No. TMPY-03708

BCA-1 Protein, Canine, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 12.1 kDa and the accession number is XP_851619.3.

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50 μg	$353	7-10 days

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Product Information

Biological Activity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	BCA-1 Protein, Canine, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 12.1 kDa and the accession number is XP_851619.3.
Species	Canine
Expression System	E. coli
Tag	N-His
Accession Number	XP_851619.3
Synonyms	chemokine (C-X-C motif) ligand 13
Construction	A DNA sequence encoding the canine CXCL13 (XP_851619.3) (Val23-Asn110) was expressed with a N-terminal polyhistidine tag. Predicted N terminal: His
Protein Purity	> 95 % as determined by SDS-PAGE
Molecular Weight	12.1 kDa (predicted); 15 kDa (reducing condition, due to glycosylation)
Endotoxin	Please contact us for more information.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	The chemokine CXCL13, also known as BCA-1 (B-cell-attracting chemokine-1) or BLC (B-lymphocyte chemoattractant), which belongs to the CXC chemokine family. CXCL13 and its receptor CXCR5 control the organization of B cells within follicles of lymphoid tissues. CXCL13 is known to dictate homing and motility of B cells in lymphoid tissue and has been implicated in the formation of ectopic lymphoid tissue in chronic inflammation. It involves in B-cell compartmental homing within secondary lymphoid organs and recently implicated in the pathogenesis of inflammatory and malignant lymphocyte-mediated diseases. In Primary central nervous system lymphoma (PCNSL), expression of BCA-1 by malignant lymphocytes and vascular endothelium may influence tumor development and localization to central nervous system (CNS). In T-lymphocytes, CXCL13 expression is thought to reflect a germinal center origin of the T-cell. CXCL13 expression may also provide an additional useful tool for the diagnosis of Angioimmunoblastic T-cell lymphoma (AITL).