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Anti-Progranulin Antibody-HRP (7I314)
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Catalog No. TMAY-01231H
Alias Pgrn, Granulin Precursor, epithelin
Anti-Progranulin Antibody-HRP (7I314) is a HRP-conjugated Mouse antibody targeting Progranulin. Anti-Progranulin Antibody-HRP (7I314) can be used in ELISA.
Anti-Progranulin Antibody-HRP (7I314)
Anti-Progranulin Antibody-HRP (7I314)
😃Good
Catalog No. TMAY-01231HAlias Pgrn, Granulin Precursor, epithelin
Anti-Progranulin Antibody-HRP (7I314) is a HRP-conjugated Mouse antibody targeting Progranulin. Anti-Progranulin Antibody-HRP (7I314) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μg | $93 | 7-10 days | |
| 100 μg | $294 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Progranulin Antibody-HRP (7I314) is a HRP-conjugated Mouse antibody targeting Progranulin. Anti-Progranulin Antibody-HRP (7I314) can be used in ELISA. |
| Alias | Pgrn, Granulin Precursor, epithelin |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 7I314 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 0.1-1 μg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Granulin / GRN (rhGRN; TMPY-00978; Met 1-Leu 593; NP_002078.1). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography and conjugated with horseradish-peroxidase (HRP). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The precursor protein, progranulin, is also called Proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth. Granulin expression inhibited Tat transactivation, and tethering experiments showed that this effect was due, at least in part, to a direct action on cyclin T1 in the absence of Tat. |
| Conjucates | HRP |
| Others Formats | Unconjugated |
| Antibody Types Available | 2 |
| Immunogen | Recombinant Human Granulin protein (TMPY-00978) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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