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Anti-CYP26A1 Antibody (6F99)

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Catalog No. TMAB-04877

Anti-CYP26A1 Antibody (6F99) is a Rabbit antibody targeting CYP26A1. Anti-CYP26A1 Antibody (6F99) can be used in WB,IHC-P,IHC-Fr,IF.

Anti-CYP26A1 Antibody (6F99)

Anti-CYP26A1 Antibody (6F99)

😃Good
Catalog No. TMAB-04877
Anti-CYP26A1 Antibody (6F99) is a Rabbit antibody targeting CYP26A1. Anti-CYP26A1 Antibody (6F99) can be used in WB,IHC-P,IHC-Fr,IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2627-10 days7-10 days
100 μL$4717-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-CYP26A1 Antibody (6F99) is a Rabbit antibody targeting CYP26A1. Anti-CYP26A1 Antibody (6F99) can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
Clone
6F99
Reactivity
Human,Mouse,Rat
Application
Recommended Dose
WB: 1:500-1000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationEndoplasmic reticulum membrane. Microsome membrane.
Tissue SpecificityHighest levels in adult liver, heart, pituitary gland, adrenal gland, placenta and regions of the brain.
ConstructionRecombinant Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThe cytochrome P450 proteins (CYPs) are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. P450 enzymes are classified into subfamilies based on their sequence similarities. CYP26A1 is a major retinoic acid catabolic enzyme. CYP26A1 plays an important role in protecting tailbud tissues from inappropriate exposure to retinoic acid. CYP26A1 transcription is epigenetically regulated by nuclear retinoic acid receptor ∫2. Mutations in the gene encoding for CYP26A1 are associated with caudal agenesis and spina bifida, imperforate anus, agenesis of the caudal portions of the digestive and urogenital tracts, and malformed lumbosacral skeletal elements. CYP26A1 is upregulated in adenomatous polyposis coli mouse adenomas, human FAP adenomas, human sporadic colon carcinomas, and in the intestine of adenomatous polyposis coli (apcmcr) mutant zebrafish embryos.
Antigen Details
Immunogen
A synthesized peptide: human Cytochrome P450 26A1
Antigen Species
Human
Gene Name
CYP26A1
Gene ID
Protein Name
Cytochrome P450 26A1
Uniprot ID
Function
Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA.
Chemical Properties
Molecular WeightTheoretical: 48 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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