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Anti-Phospho-CTNNB1 (Tyr333) Polyclonal Antibody (Synonyms: p-CTNNB1 (Y333), p-CTNNB1 (Tyr333), CTNNB1 (p-Y333...)
Catalog No. TMAC-04341 Copy Product Info
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Anti-Phospho-CTNNB1 (Tyr333) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CTNNB1 (Tyr333). Anti-Phospho-CTNNB1 (Tyr333) Polyclonal Antibody can be used in IHC,WB.
Anti-Phospho-CTNNB1 (Tyr333) Polyclonal Antibody
Copy Product Info🥰Excellent
Catalog No. TMAC-04341
Synonyms p-CTNNB1 (Y333), p-CTNNB1 (Tyr333), CTNNB1 (p-Y333), CTNNB1 (p-Tyr333)
Anti-Phospho-CTNNB1 (Tyr333) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CTNNB1 (Tyr333). Anti-Phospho-CTNNB1 (Tyr333) Polyclonal Antibody can be used in IHC,WB.
Anti-Phospho-CTNNB1
(Tyr333) Polyclonal Antibody
(Tyr333) Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $218 | 7-10 days | 7-10 days | |
| 100 μL | $318 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-Phospho-CTNNB1 (Tyr333) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CTNNB1 (Tyr333). Anti-Phospho-CTNNB1 (Tyr333) Polyclonal Antibody can be used in IHC,WB. |
| Synonyms | p-CTNNB1 (Y333), p-CTNNB1 (Tyr333), CTNNB1 (p-Y333), CTNNB1 (p-Tyr333) |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Western blot analysis of extracts from 293 cells untreated or treated with FSK using b-catenin (phospho-Tyr333) Antibody TMAC-04341. 2. Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue, using β-catenin (phospho-Tyr333) Antibody TMAC-04341.   |
| Application | |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Appearance | Liquid |
| Formulation | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 333 (Y-T-Y(p)-E-K) derived from Human b-catenin |
| Antigen Species | human |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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