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QM295

Name: QM295
Brand: TargetMol
SKU: T73536
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T73536 Copy Product Info

Purity: 99.35%

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QM295 is an inhibitor of endoplasmic reticulum oxidation 1 (ERO1) characterized by its selectively reversible thiol reactivity. ERO1 is a key enzyme in the endoplasmic reticulum of eukaryotic cells responsible for catalyzing disulfide bond formation, which is essential for proper protein folding. QM295 inhibits ERO1 activity by interacting with specific thiol groups. It serves as an effective pharmacological tool for investigating endoplasmic reticulum stress (ER stress) and the mechanisms of oxidative protein folding.

QM295

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Catalog No. T73536

Cas No. 1241046-32-1

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Pack Size	Price	USA Stock	Global Stock
1 mg	$30	-	In Stock
5 mg	$68	-	In Stock
10 mg	$107	-	In Stock
25 mg	$208	-	In Stock
1 mL x 10 mM (in DMSO)	$75	-	In Stock

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.35%

Appearance:Solid

Color:Yellow

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Product Introduction

Bioactivity

Description	QM295 is an inhibitor of endoplasmic reticulum oxidation 1 (ERO1) characterized by its selectively reversible thiol reactivity. ERO1 is a key enzyme in the endoplasmic reticulum of eukaryotic cells responsible for catalyzing disulfide bond formation, which is essential for proper protein folding. QM295 inhibits ERO1 activity by interacting with specific thiol groups. It serves as an effective pharmacological tool for investigating endoplasmic reticulum stress (ER stress) and the mechanisms of oxidative protein folding.
Targets&IC50	ERO1:1.9 uM
In vitro	QM295 (50 uM) binds to the thiol groups of ERO1, altering its conformation and leading to cellular accumulation of ERO1 alpha [1].

Chemical Properties

Molecular Weight	295.29
Formula	C₁₇H₁₃NO₄
Cas No.	1241046-32-1
Smiles	O=C1ONC(C=2C=CC=CC2)=C1C=C3C=CC(=O)C(OC)=C3

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (270.92 mM), Sonication is recommmended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3865 mL	16.9325 mL	33.8650 mL	169.3251 mL
5 mM	0.6773 mL	3.3865 mL	6.7730 mL	33.8650 mL
10 mM	0.3387 mL	1.6933 mL	3.3865 mL	16.9325 mL
20 mM	0.1693 mL	0.8466 mL	1.6933 mL	8.4663 mL
50 mM	0.0677 mL	0.3387 mL	0.6773 mL	3.3865 mL
100 mM	0.0339 mL	0.1693 mL	0.3387 mL	1.6933 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc