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SU 4981

Name: SU 4981
Brand: TargetMol
SKU: T60094
Price: 82 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60094Cas No. 186610-88-8

Alias 3-(4-Morpholinobenzylidene)indolin-2-one

SU 4981 is an inhibitor of VEGFR and a modulator of tyrosine kinase activity.

SU 4981

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Purity: 95.4%

Catalog No. T60094Alias 3-(4-Morpholinobenzylidene)indolin-2-oneCas No. 186610-88-8

SU 4981 is an inhibitor of VEGFR and a modulator of tyrosine kinase activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$82	-	In Stock
5 mg	$183	-	In Stock
10 mg	$272	-	In Stock
25 mg	$413	-	In Stock
50 mg	$580	-	In Stock
100 mg	$777	-	In Stock
200 mg	$1,030	-	In Stock
1 mL x 10 mM (in DMSO)	$182	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:95.4%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	SU 4981 is an inhibitor of VEGFR and a modulator of tyrosine kinase activity.
Targets&IC50	PDGFR:33.1 μM, VEGFR1:2.5 μM
Synonyms	3-(4-Morpholinobenzylidene)indolin-2-one

Chemical Properties

Molecular Weight	306.36
Formula	C₁₉H₁₈N₂O₂
Cas No.	186610-88-8
Smiles	C(=C1C=2C(NC1=O)=CC=CC2)C3=CC=C(C=C3)N4CCOCC4
Relative Density.	1.265 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (146.89 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2641 mL	16.3207 mL	32.6413 mL	163.2067 mL
5 mM	0.6528 mL	3.2641 mL	6.5283 mL	32.6413 mL
10 mM	0.3264 mL	1.6321 mL	3.2641 mL	16.3207 mL
20 mM	0.1632 mL	0.8160 mL	1.6321 mL	8.1603 mL
50 mM	0.0653 mL	0.3264 mL	0.6528 mL	3.2641 mL
100 mM	0.0326 mL	0.1632 mL	0.3264 mL	1.6321 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc