Shopping Cart

Your shopping cart is currently empty

Fenclonine

Name: Fenclonine
Brand: TargetMol
SKU: T1447
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T1447Cas No. 7424-00-2

Alias PCPA, Fenchlonine, DL-4-Chlorophenylalanine, CP-10188, 4-Chloro-DL-phenylalanine

Fenclonine (CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine(CP-10188) acts pharmacologically to deplete endogenous levels of serotonin.

Fenclonine

Copy Product Info

😃Good

Purity: 99.96%

Catalog No. T1447Alias PCPA, Fenchlonine, DL-4-Chlorophenylalanine, CP-10188, 4-Chloro-DL-phenylalanineCas No. 7424-00-2

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$30	In Stock	In Stock
500 mg	$42	-	In Stock
1 g	$53	-	In Stock
5 g	$126	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.96%

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Fenclonine AI Summary

Fenclonine exhibits a broad range of bioactivities across various biological assays. It notably inhibits multiple enzymes such as Endonuclease IV, Bloom's syndrome helicase (BLM), Histone Lysine Methyltransferase G9a, Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1), and Human Flap endonuclease 1 (FEN1). Additionally, it affects the human hERG channel activity, modulates Human Peripheral Myelin Protein 22 expression/activity, and enhances Arylsulfatase A (ASA1). It also interacts with HP1-beta Chromodomain and shows antiviral properties by inhibiting binding or entry of Marburg Virus and blocking Ebola Virus entry. Potencies in these assays range from 4.0 nM to 100000.0 nM. Fenclonine demonstrates notable antiviral activity against SARS-CoV-2, as evidenced by inhibiting SARS-CoV-2 induced cytotoxicity in both Caco-2 and VERO-6 cells at a concentration of 10 µM after 48 hours, showing inhibition rates of -0.58% and 0.09% respectively. Additionally, it exhibits a SARS-CoV-2 3CL-Pro protease inhibition percentage of 0.8074% at 20 µM, and an IC50 value for this antiviral activity is greater than 20000.0 nM. Furthermore, Fenclonine demonstrates inhibitory activity on human HDAC6 enzyme, showing 19.51% inhibition with a commercial peptide substrate and 6.14% with a custom peptide substrate in enzymatic assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Fenclonine (CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine(CP-10188) acts pharmacologically to deplete endogenous levels of serotonin.
Synonyms	PCPA, Fenchlonine, DL-4-Chlorophenylalanine, CP-10188, 4-Chloro-DL-phenylalanine

Chemical Properties

Molecular Weight	199.63
Formula	C₉H₁₀ClNO₂
Cas No.	7424-00-2
Smiles	NC(Cc1ccc(Cl)cc1)C(O)=O
Relative Density.	1.336 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 1 mg/mL (5.01 mM), Sonication is recommended.

DMSO: 33 mg/mL (165.31 mM), pH is adjusted to 3 with HCl. Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.0093 mL	25.0463 mL	50.0927 mL	250.4634 mL
5 mM	1.0019 mL	5.0093 mL	10.0185 mL	50.0927 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.5009 mL	2.5046 mL	5.0093 mL	25.0463 mL
20 mM	0.2505 mL	1.2523 mL	2.5046 mL	12.5232 mL
50 mM	0.1002 mL	0.5009 mL	1.0019 mL	5.0093 mL
100 mM	0.0501 mL	0.2505 mL	0.5009 mL	2.5046 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc