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Rosuvastatin calcium

Name: Rosuvastatin calcium
Brand: TargetMol
SKU: T1510
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1510Cas No. 147098-20-2

Alias ZD 4522 Calcium, Rosuvastatin hemicalcium

Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity.

Rosuvastatin calcium

🥰Excellent

Purity: 99.68%

Catalog No. T1510Alias ZD 4522 Calcium, Rosuvastatin hemicalciumCas No. 147098-20-2

Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity.

Pack Size	Price	Availability
25 mg	$35	In Stock
50 mg	$47	In Stock
100 mg	$84	In Stock
500 mg	$216	In Stock

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Purity:99.68%

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity.
Targets&IC50	HMG-CoA:11 nM
In vitro	In streptozotocin-induced diabetic rats, daily administration of Rosuvastatin (20 mg/kg) significantly reduces the content of very low-density lipoprotein (VLDL) within the body. Similarly, in male beagles with normal cholesterol levels, Rosuvastatin (3 mg/kg) effectively lowers the concentration of cholesterol in the plasma.
In vivo	In isolated rat hepatocytes (IC50=1.12 nM), Rosuvastatin acts as a high-affinity substrate for OATP-C, inhibiting cholesterol synthesis. Additionally, in endothelial cells, Rosuvastatin suppresses the expression and protein levels of ICAM-1, MCP-1, IL-8, IL-6, and COX-2 mRNA by inhibiting the c-Jun N-terminal kinase and nuclear factor-kB.
Synonyms	ZD 4522 Calcium, Rosuvastatin hemicalcium

Chemical Properties

Molecular Weight	1001.14
Formula	2(C₂₂H₂₇FN₃O₆S)Ca
Cas No.	147098-20-2
Smiles	[Ca++].CC(C)C1=C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)C(=NC(=N1)N(C)S(C)(=O)=O)C1=CC=C(F)C=C1.CC(C)C1=C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)C(=NC(=N1)N(C)S(C)(=O)=O)C1=CC=C(F)C=C1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 123 mg/mL (122.86 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (4 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9989 mL	4.9943 mL	9.9886 mL	49.9431 mL
5 mM	0.1998 mL	0.9989 mL	1.9977 mL	9.9886 mL
10 mM	0.0999 mL	0.4994 mL	0.9989 mL	4.9943 mL
20 mM	0.0499 mL	0.2497 mL	0.4994 mL	2.4972 mL
50 mM	0.0200 mL	0.0999 mL	0.1998 mL	0.9989 mL
100 mM	0.0100 mL	0.0499 mL	0.0999 mL	0.4994 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc