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GW 610
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Catalog No. T21804Cas No. 872726-44-8
GW 610 is an antitumor benzothiazole that shows growth-inhibitory activity against several cancer cell lines. In MCF-7 and MDA 468 human cancer cell lines, potent antiproliferative activity (growth inhibition (GI50) < 0.1 nM) was observed.
GW 610
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Purity: 99.23%
Catalog No. T21804Cas No. 872726-44-8
GW 610 is an antitumor benzothiazole that shows growth-inhibitory activity against several cancer cell lines. In MCF-7 and MDA 468 human cancer cell lines, potent antiproliferative activity (growth inhibition (GI50) < 0.1 nM) was observed.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $41 | In Stock | In Stock | |
| 25 mg | $96 | In Stock | In Stock | |
| 50 mg | $156 | In Stock | In Stock | |
| 100 mg | $251 | In Stock | In Stock | |
| 200 mg | $343 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.23%
Appearance:Solid
Color:Green
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Product Introduction
GW 610 AI Summary
GW 610 demonstrates potent antiproliferative activity against a range of human cancer cell lines, including MCF7, MDA-MB-468, KM12, and HCC2998, with varying GI50 values: less than 0.1 nM for MCF7 and MDA-MB-468 cells, 290.0 nM for KM12 cells, and 0.25 nM for HCC2998 cells. Additionally, it shows efficacy against HCT116 and HT29 cell lines, with GI50 values extending up to 5400.0 nM across different assays. The compound also exhibits significant bioactivity through interaction with the aryl hydrocarbon receptor (AhR), displacing [3H]tetrachlorodibenzo-p-dioxin with an IC50 of 25.0 nM and Ki of 6.8 nM. Furthermore, GW 610 exhibits cytotoxic effects on MCF10A, A549, COLO205, and MCF7 cells with IC50 values between 13940.0 nM and 25220.0 nM, induces apoptosis in COLO205 cells, and causes cell cycle arrest at various phases. The antiproliferative effects of GW 610 on MCF7 and MDA468 cells are potentiated by the aryl hydrocarbon receptor antagonist alpha-naphthoflavone..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | GW 610 is an antitumor benzothiazole that shows growth-inhibitory activity against several cancer cell lines. In MCF-7 and MDA 468 human cancer cell lines, potent antiproliferative activity (growth inhibition (GI50) < 0.1 nM) was observed. |
| Molecular Weight | 289.32 |
| Formula | C15H12FNO2S |
| Cas No. | 872726-44-8 |
| Smiles | COc1ccc(cc1OC)-c1nc2cc(F)ccc2s1 |
| Relative Density. | 1.293 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 6.5 mg/mL (22.47 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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