Anti-Phospho-MEF2C (Ser387) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-MEF2C (Ser387). Anti-Phospho-MEF2C (Ser387) Polyclonal Antibody 2 can be used in WB.

IgG

Mouse,Rat (predicted:Human,Dog,Rabbit)

Sample:
Muscle (Mouse) Lysate at 40 μg
Brain (Rat) Lysate at 40 μg
Primary: Anti-phospho-MEF2C (Ser387) (TMAB-10972) at 1/300 dilution
Secondary: HRP conjugated Goat-Anti-rabbit IgG at 1/5000 dilution
Predicted band size: 51 kD
Observed band size: 51 kD

WB: 1:500-2000

Polyclonal

KLH conjugated Synthesised phosphopeptide: human MEF2C around the phosphorylation site of Ser387

Human

MEF2C

Myocyte-specific enhancer factor 2C

Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.