Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LP-922056 is an inhibitor of Notum Pectinacetylesterase with EC50 values of 21 nM, 55 nM for human and mouse, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 30.00 | |
2 mg | In stock | $ 44.00 | |
5 mg | In stock | $ 70.00 | |
10 mg | In stock | $ 116.00 | |
25 mg | In stock | $ 226.00 | |
50 mg | In stock | $ 363.00 | |
100 mg | In stock | $ 593.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 77.00 |
Description | LP-922056 is an inhibitor of Notum Pectinacetylesterase with EC50 values of 21 nM, 55 nM for human and mouse, respectively. |
Targets&IC50 | Notum Pectinacetylesterase (mouse):55 nM (EC50), Notum Pectinacetylesterase (human):21 nM (EC50) |
In vitro | LP-922056 can be used as a complementary chemical tool for exploring the role of Notum in Wnt signaling[2]. |
In vivo | In mice, LP-922056 (3, 10, 30 mg/kg; gavage) significantly increases midshaft femur cortical bone thickness. LP-922056 (10 mg/kg) achieved high Cmax of 129 μM and AUC of 1533 μM•h while volume of distribution is 0.13 L/kg and low clearance is 0.49 mL/min•kg[1]. LP-922056 (10 mg/kg; oral) increases cortical bone thickness and strength in the midshaft femur, bone mass in the femoral neck, and vertebral body cortical shell[2]. |
Molecular Weight | 300.78 |
Formula | C11H9ClN2O2S2 |
CAS No. | 1365060-22-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 120 mg/mL (398.96 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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LP-922056 1365060-22-5 Cytoskeletal Signaling Stem Cells Wnt/beta-catenin cortical Pectinacetylesterase thickness orally femur inhibit Wnt lipase bone LP 922056 Notum Inhibitor midshaft LP922056 inhibitor