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Bis-NH2-PEG2

Name: Bis-NH2-PEG2
Brand: TargetMol
SKU: T16663
Rating: 4.5 (1 reviews)

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Catalog No. T16663Cas No. 929-59-9

Alias PROTAC Linker 19

Bis-NH2-PEG2 (PROTAC Linker 19) is a PEG-based linker compound used for synthesizing PROTACs.

Bis-NH2-PEG2

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Catalog No. T16663Alias PROTAC Linker 19Cas No. 929-59-9

Bis-NH2-PEG2 (PROTAC Linker 19) is a PEG-based linker compound used for synthesizing PROTACs.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	Inquiry	7-10 days	7-10 days
500 mg	Inquiry	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

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Product Introduction

Bioactivity

Description	Bis-NH2-PEG2 (PROTAC Linker 19) is a PEG-based linker compound used for synthesizing PROTACs.
In vitro	PROTACs consist of two ligands linked together; one targets the E3 ubiquitin ligase and the other targets the desired protein. They harness the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1].
Synonyms	PROTAC Linker 19

Chemical Properties

Molecular Weight	148.2
Formula	C₆H₁₆N₂O₂
Cas No.	929-59-9
Smiles	NCCOCCOCCN
Relative Density.	1.015 g/cm3 at 25℃ (lit.)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (1686.91 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (22.27 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.7476 mL	33.7382 mL	67.4764 mL	337.3819 mL
5 mM	1.3495 mL	6.7476 mL	13.4953 mL	67.4764 mL
10 mM	0.6748 mL	3.3738 mL	6.7476 mL	33.7382 mL
20 mM	0.3374 mL	1.6869 mL	3.3738 mL	16.8691 mL
50 mM	0.1350 mL	0.6748 mL	1.3495 mL	6.7476 mL
100 mM	0.0675 mL	0.3374 mL	0.6748 mL	3.3738 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc