Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

OptoBI-1

Name: OptoBI-1
Brand: TargetMol
SKU: T37698
Rating: 4.5 (1 reviews)

Copy Product Info

🥰Excellent

Synonyms:

Catalog No. T37698 Copy Product Info

🥰Excellent

OptoBI-1 is a photochromic, TRPC3/6/7-selective agonist based on a benzimidazole structure, with an EC₅₀ of approximately 0.1 μM for TRPC3 in its active cis conformation. OptoBI-1 can precisely regulate neuronal firing and calcium signaling in endothelial cells, and can be used to study TRPC6-dependent NFAT signaling pathways in mast cells.

Cas No. 2415272-11-4

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	$1,550	35 days	35 days
50 mg	Inquiry	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Quotation

Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding.

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Appearance:Solid

Color:Yellow

Resource Download

COA

Product Introduction

Bioactivity

Description	OptoBI-1 is a photochromic, TRPC3/6/7-selective agonist based on a benzimidazole structure, with an EC₅₀ of approximately 0.1 μM for TRPC3 in its active cis conformation. OptoBI-1 can precisely regulate neuronal firing and calcium signaling in endothelial cells, and can be used to study TRPC6-dependent NFAT signaling pathways in mast cells.
In vitro	OptoBI-1 allows precise temporal control of TRPC3-linked cellular functions, including neuronal firing and endothelial Ca 2+ transients [1].

Chemical Properties

Molecular Weight	523.67
Formula	C₃₂H₃₇N₅O₂
Cas No.	2415272-11-4
Smiles	O=C1NC=2C=CC=CC2N1C3CCN(C(=O)CCCC4=CC=C(N=NC5=CC=C(C=C5)CCCC)C=C4)CC3
Relative Density.	1.20 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 3.34 mg/mL (6.38 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9096 mL	9.5480 mL	19.0960 mL	95.4800 mL
5 mM	0.3819 mL	1.9096 mL	3.8192 mL	19.0960 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.