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Anti-CD200 Antibody-PE (9J422)
🥰Excellent
Catalog No. TMAY-01287P
Anti-CD200 Antibody-PE (9J422) is a PE-conjugated Mouse antibody targeting CD200. Anti-CD200 Antibody-PE (9J422) can be used in FCM.
Anti-CD200 Antibody-PE (9J422)
Anti-CD200 Antibody-PE (9J422)
🥰Excellent
Catalog No. TMAY-01287P
Anti-CD200 Antibody-PE (9J422) is a PE-conjugated Mouse antibody targeting CD200. Anti-CD200 Antibody-PE (9J422) can be used in FCM.
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Product Introduction
Bioactivity
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Antigen Details
Chemical Properties
| Description | Anti-CD200 Antibody-PE (9J422) is a PE-conjugated Mouse antibody targeting CD200. Anti-CD200 Antibody-PE (9J422) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 9J422 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human CD200 expression on human whole blood lymphocytes. Cells were stained with PE-conjugated anti-Human CD200. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes. |
| Application | FCM |
| Recommended Dose | 5 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD200 (rh CD200; TMPY-01071; NP_005935.4; Met1-Gly232) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Research Background | CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expressed primarily on myeloid cells. Signals delivered through the CD200:CD200R axis have been shown to play an important role in the regulation of anti-tumor immunity, and overexpression of CD200 has been reported in a number of malignancies, including CLL, as well as on cancer stem cells. The role of CD200-CD200R signaling in immune regulation of the central nervous system has become a popular field of research in recent years. Many studies have shown that there is a close correlation between CD200-CD200R, microglia activation, and Parkinson's disease (PD). The ability of CD200 to suppress myeloid cell activation is critical for maintaining normal tissue homeostasis but may also enhance the survival of migratory neoplastic cells. CD200 and CD200R associate via their respective N-terminal Ig-like domains. CD200 has been characterized as an important immunoregulatory molecule, increased expression of which can lead to decreased transplant rejection, autoimmunity, and allergic disease. Elevated CD200 expression has been reported to be associated with poor prognosis in some human malignancies. Besides, CD200 also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | PE |
| Others Formats | Unconjugated |
| Antibody Types Available | 2 |
| Immunogen | Recombinant Human CD200 Protein (TMPY-01071) |
| Antigen Species | Human |
| Biology Area | Neuroinflammation, Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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