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Bromopride

Name: Bromopride
Brand: TargetMol
SKU: T1175
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1175Cas No. 4093-35-0

Alias Valopride, Bromoprida, Artomey

Bromopride (Valopride) is a dopamine antagonist with prokinetic properties closely related to metoclopramide, and is widely used as an antiemetic. It is not available in the United States or the United Kingdom.

Bromopride

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Purity: 99.95%

Catalog No. T1175Alias Valopride, Bromoprida, ArtomeyCas No. 4093-35-0

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	In Stock	In Stock
5 mg	$56	In Stock	In Stock
10 mg	$89	In Stock	In Stock
25 mg	$179	In Stock	In Stock
50 mg	$289	In Stock	In Stock
100 mg	$455	In Stock	In Stock
200 mg	$662	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$62	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.95%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bromopride AI Summary

Bromopride is a multifaceted bioactive molecule exhibiting a wide range of activities on different cellular targets and enzymes. It inhibits acid sphingomyelinase (ASM) in human H4 cells, presenting a residual activity of 90.5% at 10 μM. With a pKa of 9.35 and a partition coefficient (log P) of 2.83, it also shows significant distribution properties indicated by a LogD7.4 of 0.54. Bromopride has demonstrated total body clearance of 13.0 mL.min^-1.kg^-1 and renal clearance of 1.4 mL.min^-1.kg^-1 in humans, along with a half-life of 2.9 hours, a volume of distribution at steady state (Vdss) of 3.1 L.kg^-1, and a mean residence time (MRT) of 4.0 hours after IV administration. Bioactivity assays reveal that Bromopride inhibits several enzymes and targets: - It exerts inhibitory activity against AmpC Beta-Lactamase (7943.3 nM), Cytochrome P450 2D6 (5011.9 nM), malarial parasite plastid (14715.7 nM), and TGF-b (14125.4 nM). - It is an inhibitor of Glutaminase (11220.2 nM) and USP1/UAF1 (39810.7 nM). - It demonstrates potent activity in the S16 Schwann cell PMP22 intronic element firefly luciferase assay (287.0 nM). Furthermore, Bromopride inhibits sodium fluorescein uptake in OATP1B3-transfected CHO cells by 93.15% and in OATP1B1-transfected CHO cells by 85.77% at 10 μM. Despite showing negligible inhibition on the bile salt export pump (BSEP) and multiple drug resistance-associated proteins (MRP2, MRP3, MRP4), it suggests minimal interaction with these transport proteins. In antiviral assays, Bromopride demonstrates varied efficacy against SARS-CoV-2, including inhibition of SARS-CoV-2 induced cytotoxicity in different cell lines and partial inhibition of the SARS-CoV-2 3CL-Pro protease. It shows low inhibition rates in Vero E6 and Caco-2 cells, indicating limited efficacy in these systems. Additional bioactivities include moderate binding affinity towards human DRD1, moderate antagonist activity at TBXA2R, and agonist activity at HTR1A and ADRA1A. It does not significantly inhibit HDAC6 activity with slight inhibition varying based on the peptide substrate. Overall, Bromopride exhibits diverse bioactivities and demonstrates potential inhibitory actions on various cellular mechanisms..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Bromopride (Valopride) is a dopamine antagonist with prokinetic properties closely related to metoclopramide, and is widely used as an antiemetic. It is not available in the United States or the United Kingdom.
Synonyms	Valopride, Bromoprida, Artomey

Chemical Properties

Molecular Weight	344.25
Formula	C₁₄H₂₂BrN₃O₂
Cas No.	4093-35-0
Smiles	C(NCCN(CC)CC)(=O)C1=C(OC)C=C(N)C(Br)=C1
Relative Density.	1.313g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (145.24 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9049 mL	14.5243 mL	29.0487 mL	145.2433 mL
5 mM	0.5810 mL	2.9049 mL	5.8097 mL	29.0487 mL
10 mM	0.2905 mL	1.4524 mL	2.9049 mL	14.5243 mL
20 mM	0.1452 mL	0.7262 mL	1.4524 mL	7.2622 mL
50 mM	0.0581 mL	0.2905 mL	0.5810 mL	2.9049 mL
100 mM	0.0290 mL	0.1452 mL	0.2905 mL	1.4524 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc