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Anti-CD82 Antibody (8X895)
😃Good
Catalog No. TMAY-02305
Alias TSPAN27, ST6, SAR2, R2, KAI-1, KAI1, IA4, GR15, CD82 molecule, C33, 4F9
Anti-CD82 Antibody (8X895) is a Mouse antibody targeting CD82. Anti-CD82 Antibody (8X895) can be used in IHC-P.
Anti-CD82 Antibody (8X895)
Anti-CD82 Antibody (8X895)
😃Good
Catalog No. TMAY-02305Alias TSPAN27, ST6, SAR2, R2, KAI-1, KAI1, IA4, GR15, CD82 molecule, C33, 4F9
Anti-CD82 Antibody (8X895) is a Mouse antibody targeting CD82. Anti-CD82 Antibody (8X895) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: IHC-P Reactivity: Human |
| Alias | TSPAN27, ST6, SAR2, R2, KAI-1, KAI1, IA4, GR15, CD82 molecule, C33, 4F9 |
| Ig Type | Mouse IgG1 |
| Clone | 8X895 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human CD82 in human tonsil with mouse monoclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections. 2. Immunochemical staining of human CD82 in human appendix with mouse monoclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections. 3. Immunochemical staining of human CD82 in human spleen with mouse monoclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections. |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:400-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD82/KAI-1 (rh CD82/KAI-1; TMPY-02030; P27701-1; Gly111-Leu228). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | CD82, also known as KAI-1, structurally belongs to tetraspanin family while categorised as metastasis suppressor gene on functional grounds. KAI1/CD82 is localized on cell membrane and form interactions with other tetraspanins, integrins and chemokines which are respectively responsible for cell migration, adhesion and signalling. Downregulation of CD82 expression is associated with the advanced stages of many human cancers and correlates with the acquisition of metastatic potential. Recent studies suggest that complex mechanisms underlie CD82 loss of function, including altered transcriptional regulation, splice variant production and post-translational protein modifications, and indicate a central role for CD82 in controlling metastasis as a 'molecular facilitator'. The loss of KAI1/CD82 expression in invasive and metastatic cancers is due to a complex, epigenetic mechanism that probably involves transcription factors such as NFkappaB, p53, and beta-catenin. A loss of KAI1 expression is also associated with the advanced stages of many human malignancies and results in the acquisition of invasive and metastatic capabilities by tumour cells. Thus, KAI1/CD82 is regarded as a wide-spectrum tumor metastasis suppressor. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human CD82/KAI-1 Protein (TMPY-02030) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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