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TargetMol | Compound Library

JAK-STAT Compound Library

Catalog No. L3700

Cell signal transduction is the transmission of molecular signals via various proteins in a signaling cascade, which carries and amplifies the signal. The JAK-STAT signaling pathway communicates information from chemical signals outside of a cell to the cell nucleus, resulting in the activation of genes through a process called transcription. There are three key parts of JAK-STAT signaling: Janus kinases (JAKs), Signal Transducer and Activator of Transcription proteins (STATs), and receptors (which bind the chemical signals). JAK-STAT signaling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death and tumor formation. Disrupted JAK-STAT signaling may lead to a variety of diseases, such as skin conditions, cancers, and disorders affecting the immune system. There are 4 JAK proteins: JAK1, JAK2, JAK3 and TYK2, and there are 7 STAT proteins: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6. JAK/STAT Compound Library from TargetMol, a unique collection of 415 compounds targeting JAK/STAT signaling, can be used for research in JAK/STAT signaling and related drug screening (high throughput and high content screening).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L3700

JAK-STAT Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 415 JAK/STAT signaling targeted compounds for high throughput and high content screening;
  • Effective tool for studying the JAK/STAT targets;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Packaging And Storage | TargetMol Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

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Targetmol Compound Libraries
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Library Customization | TargetMol Library Composition

EGFR
JAK
STAT
Apoptosis
Autophagy
Potassium Channel
HER
Tyrosine Kinases
Pim
FLT
VEGFR
NF-κB
Src
CDK
FGFR
PDGFR
ERK
Bcr-Abl
Endogenous Metabolite
p38 MAPK
Parasite
IL Receptor
COX
Antibacterial
IGF-1R
Akt
5-HT Receptor
c-RET
TNF
HIV Protease
Ferroptosis
c-Met/HGFR
Aurora Kinase
Cytochromes P450
IκB/IKK
c-Kit
Sodium Channel
Antibiotic
BTK
Histone Methyltransferase
JNK
PKA
Caspase
Calcium Channel
PKC
Drug Metabolite
Interleukin
DNA/RNA Synthesis
TLR
ALK
Beta Amyloid
AMPK
MEK
AChR
Syk
HCV Protease
PI3K
Antioxidant
DYRK
Histamine Receptor
Phosphatase
Virus Protease
Wnt/beta-catenin
Topoisomerase
RIP kinase
Raf
Reactive Oxygen Species
Somatostatin
mTOR
P-gp
HSP
Bcl-2 Family
Histone Acetyltransferase
Casein Kinase
Influenza Virus
Hippo pathway
c-Fms
HDAC
FAK
MLK
NO Synthase
Melanin-concentrating Hormone Receptor (MCHR)
GPCR
NOS
Dopamine Receptor
Integrin
Na+/Ca2+ Exchanger
IFNAR
GTPase
Mitophagy
GSK-3
OCT
Estrogen Receptor/ERR
HBV
Cholecystokinin Receptor
Serine/threonin kinase
Cysteine Protease
Nucleoside Antimetabolite/Analog
PYK2
TRP/TRPV Channel
ROCK
Adrenergic Receptor
CSF-1R
UGT
PDE
NMDAR
Antifection
ROS
FAAH
CCR
ACK1
PTEN
MMP
Chk
cAMP
GluR
Thrombopoietin Receptor
Epigenetic Reader Domain
CaMK
DUB
TGF-beta/Smad
Survivin
MNK
Antiviral
Trk receptor
Sirtuin
Ephrin Receptor
Nrf2
hCE
RSV
MELK
ATM/ATR
Reverse Transcriptase
PLK
HIF
SGK
DAPK
Anti-infection
NADPH-oxidase
IRAK
S6 Kinase
Ras
Sigma receptor
Tyrosinase
HIF/HIF Prolyl-Hydroxylase
ROS Kinase
PD-1/PD-L1
Monoamine Oxidase

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