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TargetMol | Compound Library

JAK-STAT Compound Library

Catalog No. L3700

Cell signal transduction is the transmission of molecular signals via various proteins in a signaling cascade, which carries and amplifies the signal. The JAK-STAT signaling pathway communicates information from chemical signals outside of a cell to the cell nucleus, resulting in the activation of genes through a process called transcription. There are three key parts of JAK-STAT signaling: Janus kinases (JAKs), Signal Transducer and Activator of Transcription proteins (STATs), and receptors (which bind the chemical signals). JAK-STAT signaling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death and tumor formation. Disrupted JAK-STAT signaling may lead to a variety of diseases, such as skin conditions, cancers, and disorders affecting the immune system. There are 4 JAK proteins: JAK1, JAK2, JAK3 and TYK2, and there are 7 STAT proteins: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6. JAK/STAT Compound Library from TargetMol, a unique collection of 252 compounds targeting JAK/STAT signaling, can be used for research in JAK/STAT signaling and related drug screening (high throughput and high content screening).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L3700

JAK-STAT Compound Library
sizeIn stock
  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;
  • Effective tool for studying the JAK/STAT targets;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Packaging And Storage | TargetMol Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

Library Customization | TargetMol Library Customization

Compound Library | TargetMol
Targetmol Compound Libraries
can be highly customized!
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Library Customization | TargetMol Library Composition

EGFR
JAK
STAT
Apoptosis
Autophagy
HER
Tyrosine Kinases
FLT
Src
VEGFR
Pim
CDK
PDGFR
NF-κB
FGFR
Potassium Channel
Antibacterial
Parasite
Endogenous Metabolite
Antibiotic
HIV Protease
p38 MAPK
Bcr-Abl
IL Receptor
Somatostatin
IκB/IKK
c-RET
Histone Methyltransferase
Ferroptosis
ERK
BTK
IGF-1R
COX
Interleukin
Influenza Virus
AMPK
Syk
c-Kit
HCV Protease
IFNAR
Mitophagy
Virus Protease
Estrogen Receptor/ERR
Caspase
PKC
Reactive Oxygen Species
Aurora Kinase
Akt
TLR
Beta Amyloid
5-HT Receptor
MEK
TNF
Sodium Channel
NOS
Dopamine Receptor
Integrin
Estrogen/progestogen Receptor
Antifungal
PI3K
Antioxidant
Na+/Ca2+ Exchanger
Histamine Receptor
JNK
Phosphatase
GSK-3
PKA
HBV
Wnt/beta-catenin
Cysteine Protease
Nucleoside Antimetabolite/Analog
Calcium Channel
ROCK
Adrenergic Receptor
Topoisomerase
UGT
PDE
Raf
Drug Metabolite
ROS
BCL
FAAH
CXCR
PTEN
Chk
MMP
cAMP
TGF-beta/Smad
DNA/RNA Synthesis
Survivin
P-gp
HSP
Trk receptor
Histone Acetyltransferase
Nrf2
hCE
ALK
Casein Kinase
Hippo pathway
Reverse Transcriptase
HDAC
c-Fms
P450
HIF
PLK
AChR
Anti-infection
NADPH-oxidase
Ras
cholecystokinin
HIF/HIF Prolyl-Hydroxylase
FAK
PD-1/PD-L1
NO Synthase
Monoamine Oxidase

Keywords