Select your Country or Region

  • TargetMol | Compound LibraryArgentinaArgentina
  • TargetMol | Compound LibraryAustraliaAustralia
  • TargetMol | Compound LibraryAustriaAustria
  • TargetMol | Compound LibraryBelgiumBelgium
  • TargetMol | Compound LibraryBrazilBrazil
  • TargetMol | Compound LibraryBulgariaBulgaria
  • TargetMol | Compound LibraryCroatiaCroatia
  • TargetMol | Compound LibraryCyprusCyprus
  • TargetMol | Compound LibraryCzechCzech
  • TargetMol | Compound LibraryDenmarkDenmark
  • TargetMol | Compound LibraryEgyptEgypt
  • TargetMol | Compound LibraryEstoniaEstonia
  • TargetMol | Compound LibraryFinlandFinland
  • TargetMol | Compound LibraryFranceFrance
  • TargetMol | Compound LibraryGermanyGermany
  • TargetMol | Compound LibraryGreeceGreece
  • TargetMol | Compound LibraryHong KongHong Kong
  • TargetMol | Compound LibraryHungaryHungary
  • TargetMol | Compound LibraryIcelandIceland
  • TargetMol | Compound LibraryIndiaIndia
  • TargetMol | Compound LibraryIrelandIreland
  • TargetMol | Compound LibraryIsraelIsrael
  • TargetMol | Compound LibraryItalyItaly
  • TargetMol | Compound LibraryJapanJapan
  • TargetMol | Compound LibraryKoreaKorea
  • TargetMol | Compound LibraryLatviaLatvia
  • TargetMol | Compound LibraryLebanonLebanon
  • TargetMol | Compound LibraryMalaysiaMalaysia
  • TargetMol | Compound LibraryMaltaMalta
  • TargetMol | Compound LibraryMoroccoMorocco
  • TargetMol | Compound LibraryNetherlandsNetherlands
  • TargetMol | Compound LibraryNew ZealandNew Zealand
  • TargetMol | Compound LibraryNorwayNorway
  • TargetMol | Compound LibraryPolandPoland
  • TargetMol | Compound LibraryPortugalPortugal
  • TargetMol | Compound LibraryRomaniaRomania
  • TargetMol | Compound LibrarySingaporeSingapore
  • TargetMol | Compound LibrarySlovakiaSlovakia
  • TargetMol | Compound LibrarySloveniaSlovenia
  • TargetMol | Compound LibrarySpainSpain
  • TargetMol | Compound LibrarySwedenSweden
  • TargetMol | Compound LibrarySwitzerlandSwitzerland
  • TargetMol | Compound LibraryTaiwan,ChinaTaiwan,China
  • TargetMol | Compound LibraryThailandThailand
  • TargetMol | Compound LibraryTurkeyTurkey
  • TargetMol | Compound LibraryUnited KingdomUnited Kingdom
  • TargetMol | Compound LibraryUnited StatesUnited States
  • TargetMol | Compound LibraryOther CountriesOther Countries
Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
Filter
TargetMol | Tags Chromatin/Epigenetic
TargetMol | Tags Metabolism

HIF/HIF Prolyl-Hydroxylase

HIF prolyl-hydroxylase is an enzyme involved in the HIF (Hypoxia-inducible factor) signalling pathways, and is the target for a set of therapeutic drugs called HIF prolyl-hydroxylase inhibitors. Hypoxia-inducible factor (HIF) is an evolutionarily conserved transcription factor that allows the cell to respond physiologically to low concentrations of oxygen. A class of prolyl hydroxylases which act specifically on HIF has been identified; hydroxylation of HIF allows the protein to be targeted for degradation.

  • PX-478
    T6961685898-44-6
    PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability. PX-478 has antitumor activity and also protects pancreatic β-cell function in diabetes mellitus and is used in type 2 diabetes mellitus research.
    • $48
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Deferoxamine Mesylate
    T1637138-14-7
    Deferoxamine Mesylate (DFOM) is an iron chelator and ferroptosis inhibitor. Deferoxamine Mesylate binds free iron into a stable complex and reduces iron accumulation. Deferoxamine Mesylate up-regulates HIF-1α levels and induces apoptosis.
    • $31
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Hydroxycitric acid tripotassium hydrate
    T115896100-05-6
    Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation, and anti-tumor effects. Hydroxycitric acid tripotassium hydrate(Potassium citrate monohydrate) (Potassium citrate monohydrate) is the major active ingredient of Garcinia cambogia and a derivative of citric acid. Hydroxycitric acid tripotassium hydrate(Potassium citrate monohydrate) competitively inhibits ATP citrate lyase with weight loss benefits.
    • $76
    In Stock
    Size
    QTY
  • Glucosamine
    T04293416-24-8
    Glucosamine (Chitosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to rebuild cartilage and treat arthritis.
    • $50
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • AKB-6899
    T297971007377-55-0In house
    AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages. AKB-6899 leads to stabilization of HIF-2α which induces sVEGFR-1 production from tumor-associated macrophages and decreases tumor growth.
    • $68
    In Stock
    Size
    QTY
  • HIF-2α agonist 2
    T678312750141-15-0In house
    HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α. HIF-2α agonist 2 can promote the stability of the ARNT A/B ring in the 3z structure of HIF-2a-ARNT complex without cytotoxicity to 786-o-Reha-Luc cells. HIF-2α agonist 2 can be used in the study of oxygen metabolism and is closely related to the occurrence of cancer.
    • $51
    In Stock
    Size
    QTY
  • 1,4-DPCA
    T21653331830-20-7In house
    1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HIF (FIH).
    • $47
    In Stock
    Size
    QTY
  • PT-2385
    T78481672665-49-4In house
    PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).
    • $61
    In Stock
    Size
    QTY
  • Deoxyshikonin
    T5S234743043-74-9
    1. Deoxyshikonin (Arnebin 7) may be a new drug candidate for wound healing and treatment of lymphatic diseases. 2. Deoxyshikonin enhances the ability of human dermal lymphatic microvascular endothelial cells (HMVEC-dLy) to undergo time-dependent in vitro cord formation. 3. Deoxyshikonin and dodecyl gallate show significantly synergic antimicrobial activity with penicillin in vivo and in vitro, and can effectively reduce nasopharyngeal and lung colonization caused by different penicillin-resistant pneumococcal serotypes.
    • $130
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • IDF-11774
    T55371429054-28-3
    IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).
    • $55
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • BAY 87-2243
    T24881227158-85-1
    BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).
    • $38
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Chlorogenic Acid
    T2805327-97-9
    Chlorogenic acid, as a major phenolic compound in honeysuckle, possesses potential antioxidant, antibacterial, anti-inflammatory, and anticancer activities. It can be utilized in research related to the treatment of advanced cancer and impaired glucose tolerance.
    • $50
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Chloramphenicol
    T120556-75-7
    Chloramphenicol (Chloromycetin), a broad-spectrum antibiotic, blocks bacterial protein synthesis.
    • $41
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • AKBA
    T5S156967416-61-9
    AKBA (3-O-Acetyl-11-keto-beta-boswellic acid), a natural component from frankincense, is a novel activator of Nrf2.
    • $36
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Minocycline hydrochloride
    T110113614-98-7
    Minocycline hydrochloride (Minocycline HCl) is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for several bacterial infections as well as treatment of acne. Minocycline hydrochloride can cause both an acute hepatitis-like syndrome occurring within 1 to 3 months of starting therapy or a more insidious chronic hepatitis with autoimmune features typically after long-term treatment.
    • $38
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Oroxylin A
    T6S1315480-11-5
    1. Oroxylin A (Baicalein 6-methyl ether) has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production via modulation of LAP/LIP/CHOP in leukemia cell lines, which could providing a therapeutic strategy for RAS. 3. Oroxylin A inhibits UCP2s triggers the MPTP opening, and promotes the apoptosis in CaCo-2 cells; uncoupling protein 2 plays a key role in mitochondrial apoptotic pathway. 4. Oroxylin A inhibits N1ICD translocating to the nucleus and binding to epithelial-mesenchymal transition-related transcription factor Snail, thus suppressing the invasion and migration of MCF-7 cells. 5. Oroxylin A improves the sensitivity of K562/ADM cells by increasing apoptosis in leukemic cells and decreasing the expression of CXCR4 and PI3K/Akt/NF-κB pathway, and probably served as a most promising agent for CML treatment.
    • $140
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • DMOG
    T193989464-63-1
    DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.
    • $47
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • LW6
    T3494934593-90-5
    LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor.
    • $39
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • KC7F2
    T3169927822-86-4
    KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.
    • $43
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Roxadustat
    T2515808118-40-3
    Roxadustat (FG-4592) is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), with potential anti-anemic activity.
    • $30
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Molidustat
    T26521154028-82-6
    Molidustat (BAY 85-3934)(BAY-85-3934), an inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylase (PH), stimulates erythropoietin (EPO) production and the formation of red blood cells.
    • $45
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Izilendustat
    T643361303512-02-8
    Tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate inhibit of human recombinant EGLN-1 as substrate after 20 mins by mass spectrophotometric analysis.
    • $39
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • HIF-2α-IN-2
    T115611672666-82-8
    HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).
    • $108
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • HIF-1α-IN-6
    T82198
    HIF-1α-IN-6 (compound 3s) is a potent inhibitor of HIF-1α, demonstrating IC50 values of 0.6 nM and 53.3 nM in MiaPaCa-2 and MDA-MB-231 cells, respectively. It suppresses HIF-1α expression through the reduction of HIF-1α mRNA levels [1].
    • Inquiry Price
    Size
    QTY
    TargetMol | Inhibitor Sale
  • HIF-1 alpha (556-574) (TFA)
    T82199
    HIF-1 alpha (556-574) TFA is a 19-residue fragment of hypoxia-inducible factor-1 (HIF-1), which serves as the master regulator of oxygen homeostasis [1].
    • Inquiry Price
    Size
    QTY
    TargetMol | Inhibitor Sale
  • EHP-101
    T132891818428-24-8
    EHP-101 (VCE-004.8) is a specific dual agonist of PPARγ and CB2 receptor with potent anti-inflammatory activity. EHP-101 attenuates adipogenesis and prevents diet-induced obesity.
    • $109
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • PHD-IN-2
    T797982924182-42-1
    PHD-IN-2 (Compound 91), a potent PHD antagonist with an IC50 of less than 5 nM, effectively stimulates erythropoietin synthesis in HEP3B cells with an EC50 of less than 2.5 μM. It is applicable for research purposes across various medical fields, including cardiovascular, metabolic, hematological, pulmonary, kidney, liver, and wound healing disorders, as well as cancer [1].
    • Inquiry Price
    Size
    QTY
  • β,β-Dimethylacrylshikonin
    T3S234424502-79-2
    1. β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significantly suppressed tumor growth of the HCT-116 xenograft. (b) Dimethylacrylshikonin significantly suppressed the growth of H(22) transplantable hepatoma, and induced the activation of caspase-3 . (c) Dimethylacrylshikonin inhibited growth of gastric cancer SGC-791 cells by inducing ERK signaling pathway. 2. Dimethylacrylshikonin inhibits the proliferation of MCF-7 cells in vitro by inducing apoptosis through the downregulation of Bcl-2, upregulation of Bax and partial inactivation of the NF-κB pathway.
    • $130
    In Stock
    Size
    QTY
  • Amifostine trihydrate
    T6381112901-68-5
    Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.
    • $31
    In Stock
    Size
    QTY
  • Enarodustat
    T152191262132-81-9
    Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.
    • $33
    In Stock
    Size
    QTY
  • Glucosamine sulfate
    T279229031-19-4
    Glucosamine sulfate (D-Glucosaminesulfate) was extracted from synthetic product;Store the product in sealed, cool and dry condition.
    • $41
    In Stock
    Size
    QTY
  • Glucosamine hydrochloride
    T294166-84-2
    Glucosamine hydrochloride (Chitosamine hydrochloride) is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.
    • $41
    In Stock
    Size
    QTY
  • Albendazole
    T115254965-21-8
    Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.
    • $40
    In Stock
    Size
    QTY
  • Vadadustat
    T46511000025-07-9
    Vadadustat is a novel, titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor in development for the treatment of anemia.
    • $42
    In Stock
    Size
    QTY
  • TM6089
    T17105863421-32-3
    TM6089 is an inhibitor of Prolyl Hydroxylase that stimulates HIF activity without iron chelation, induces angiogenesis, and protects organ against ischemia.
    • $113
    In Stock
    Size
    QTY
  • MK-8617
    T41061187990-87-9
    MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1 2 3 (IC50: 1.0 1.0 14 nM).
    • $30
    In Stock
    Size
    QTY
  • Citric acid trilithium salt tetrahydrate
    T02566080-58-6
    Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways and metabolic in the brain based on the particular disease and clinical condition model. According to the reports, Citric acid trilithium salt tetrahydrate was used as a mood stabilizer when treating bipolar mood disorders (BD) and lower the risk of self-harm in BD patient. In addition,Citric acid trilithium salt tetrahydrate has been the choice drug in the therapy of acute manic episodes.Citric acid trilithium salt tetrahydrate also could dissolve uric acid crystals in urine achieved from patients with gout. Besides,Citric acid trilithium salt tetrahydrate have some dose-dependent side-effects. The the main side-effects of Lithium Citrate is the tendency to inhibit the prostatic acid phosphatase enzyme (PAP), which result in the accumulation of PAP.
    • $29
    In Stock
    Size
    QTY
  • Fraxinellone
    T6S007128808-62-0
    1. Fraxinellone significantly reduced weight loss and diarrhea in mice and alleviated the macroscopic and microscopic signs of the disease. 2. Fraxinellone exhibited a variety of insecticidal activities including feeding-deterrent activity, inhibition of growth, and larvicidal activity. 3. Fraxinellone has effect in the midgut metabolism of Mythimna separata (M. separata), via protease (especially the weak alkaline trypsin-like enzyme), carboxylesterase and glutathione S-transferase.
    • $66
    In Stock
    Size
    QTY
  • SYP-5
    T130501384268-04-5
    SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.
    • $38
    In Stock
    Size
    QTY
  • Oltipraz
    T015364224-21-1
    Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD(P)H: quinone oxidoreductase 1 (NQO1). The induction of detoxification enzymes enhances the detoxification of certain cancer-causing agents, thereby enhancing their elimination and preventing carcinogen-induced DNA damages. Although the exact mechanism through which the anti-angiogenesis effect remains to be fully elucidated, oltipraz maybe able to modulate the expression of a number of angiogenic factors, thereby blocking the sustained and focal neovascularization in multiple tumor cell types.
    • $31
    In Stock
    Size
    QTY
  • Panaxadiol
    T276319666-76-3
    Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.
    • $50
    In Stock
    Size
    QTY
  • TP0463518
    T53921558021-37-6
    TP-0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor (IC50s: 13 nM and 18 nM for human and rat PHD2, respectively).
    • $47
    In Stock
    Size
    QTY
  • HIF-1α-IN-2 hydrochloride
    T78123
    HIF-1α-IN-2 hydrochloride is a potent HIF-1α inhibitor exhibiting anticancer activity, demonstrated by IC50 values of 28 nM in MDA-MB-231 cells and 15 nM in MiaPaCa-2 cells. It effectively suppresses HIF-1α expression by inhibiting both transcription and protein translation [1].
    • Inquiry Price
    Size
    QTY
  • HIV-IN-7
    T78834
    Axl-IN-16 (Compound 4), an Axl inhibitor, not only suppresses Axl expression and HIF activity but also triggers fruiting body formation in Flammulina velutipes. This compound can be extracted from the fruiting liquid (FL) of Hypholoma lateritium and Hericium erinaceus [1].
    • Inquiry Price
    Size
    QTY
  • HIF-2α-IN-9
    T789372648334-36-3
    HIF-2α-IN-9 (compound 35r) serves as an HIF-2α inhibitor, effectively suppressing VEGF-A with an IC50 of 305 nM, and modulating growth-promoting genes within tumor cells while reactivating macrophage-mediated tumor immunity [1].
    • $1,820
    Backorder
    Size
    QTY
  • VHL-IN-1
    T79720
    VHL-IN-1 (compound 30), a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor with a dissociation constant (Kd) of 37 nM, potently stabilizes HIF-1α and enhances its transcriptional activity. It shows promise for applications as a HIF-1α stabilizer and for the degradation of proteolytically targeted chimeras (PROTACs) [1].
    • Inquiry Price
    Size
    QTY
  • IOX4
    T78801154097-71-8
    IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)
    • $30
    In Stock
    Size
    QTY
  • Tilorone dihydrochloride
    T024427591-69-1
    Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions.
    • $58
    In Stock
    Size
    QTY
  • Angiogenesis agent 1
    T742172765218-28-6
    Angiogenesis Agent 1 (Compound C-31), a glycoside analogue derived from salidroside, acts as an activator of the HIF-1α pathway and shows potential in diabetic hind limb ischemia research [1].
    • $1,520
    Backorder
    Size
    QTY
  • Fenbendazole
    T114143210-67-9
    Fenbendazole (Fenbendazol) is an antinematodal benzimidazole used in veterinary medicine.
    • $33
    In Stock
    Size
    QTY