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INX-315

Name: INX-315
Brand: TargetMol
SKU: T86723
Price: 397 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T86723Cas No. 2745060-92-6

INX-315 is an orally active, selective CDK2 inhibitor that induces cell cycle arrest and senescence in solid tumours, suppresses E2F target gene expression, and exhibits anticancer activity in ccne1-amplified cancers and cdk4/6i-resistant intraductal breast cancer models.

INX-315

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Purity: 99.88%

Catalog No. T86723Cas No. 2745060-92-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$67	-	In Stock
5 mg	$162	-	In Stock
10 mg	$293	In Stock	In Stock
25 mg	$397	-	In Stock
50 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$198	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.88%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	INX-315 is an orally active, selective CDK2 inhibitor that induces cell cycle arrest and senescence in solid tumours, suppresses E2F target gene expression, and exhibits anticancer activity in ccne1-amplified cancers and cdk4/6i-resistant intraductal breast cancer models.
In vitro	INX-315 (30-300 nM, 24 hours) treatment of OVCAR3 and MKN1 cells effectively inhibited cell cycle progression by downregulating the phosphorylation of retinoblastoma protein (Rb) [1]. INX-315 (0.3 nM - 10 μM, 6 days) treatment of CCNE1-amplified ovarian cancer cell lines significantly suppressed cell proliferation [1].
In vivo	In the BALB/c nude mouse model of gastric adenocarcinoma, oral administration of INX-315 at a dose of 100 mg/kg (twice daily for 56 consecutive days) effectively inhibited tumor growth [1]. In the OVCAR3 ovarian cancer Parazacco spilurus subsp. In a Spilurus xenograft model, intraperitoneal injection of INX-315 at doses of 100 mg/kg (twice daily) or 200 mg/kg (once daily) for 42 days demonstrated significant tumor suppression and was well tolerated [2]. In the GA0103 gastric cancer Parazacco spilurus subsp. spilurus xenograft model, intraperitoneal injection of INX-315 at a dose of 100 mg/kg (twice daily for 56 consecutive days) exhibited notable antitumor activity with favorable tolerability [2].

Chemical Properties

Molecular Weight	427.48
Formula	C₁₉H₂₁N₇O₃S
Cas No.	2745060-92-6
Smiles	O=C1NNC2=CC=3C=NC(=NC3N2C14CCCCC4)NC5=CC=C(C=C5)S(=O)(=O)N

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL (187.14 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (7.72 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3393 mL	11.6965 mL	23.3929 mL	116.9645 mL
5 mM	0.4679 mL	2.3393 mL	4.6786 mL	23.3929 mL
10 mM	0.2339 mL	1.1696 mL	2.3393 mL	11.6965 mL
20 mM	0.1170 mL	0.5848 mL	1.1696 mL	5.8482 mL
50 mM	0.0468 mL	0.2339 mL	0.4679 mL	2.3393 mL
100 mM	0.0234 mL	0.1170 mL	0.2339 mL	1.1696 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

INX-315

INX-315

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In Vivo Formulation Calculator (Clear solution)

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