Anti-Phospho-TAOK 1/2/3 (Ser181/Ser181/Ser177) Antibody (2Y379) is a Rabbit antibody targeting Phospho-TAOK 1/2/3 (Ser181/Ser181/Ser177). Anti-Phospho-TAOK 1/2/3 (Ser181/Ser181/Ser177) Antibody (2Y379) can be used in WB,IHC-P,IHC-Fr,IF.

IgG

2Y379

Human,Mouse,Rat

WB: 1:1000-2000; IHC-P: 1:100-200; IHC-Fr: 1:100-200; IF: 1:100-200

Monoclonal

A synthesized peptide: human TAOK 1/2/3 around the phosphorylation site of S181/S181/S177

Human

TAOK2

Serine/threonine-protein kinase TAO2

Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1, but not isoform 2, activates the JNK MAP kinase pathway through the specific activation of the upstream MKK3 and MKK6 kinases. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of IKKA, and thus NF-kappa-B activation, but not that of JNK. Phosphorylates itself, MBP, activated MAPK8 and tubulins. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization (By similarity). Both isoforms are involved in MAPK14 phosphorylation.