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Pantoprazole Sodium Hydrate

Name: Pantoprazole Sodium Hydrate
Brand: TargetMol
SKU: T0161
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0161Cas No. 164579-32-2

Alias SKF96022 sodium hydrate, SKF96022 (sodium hydrate), BY1023 (sodium hydrate)

Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.

Pantoprazole Sodium Hydrate

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Purity: 98.32%

Catalog No. T0161Alias SKF96022 sodium hydrate, SKF96022 (sodium hydrate), BY1023 (sodium hydrate)Cas No. 164579-32-2

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$30	-	In Stock
500 mg	$88	-	In Stock
1 g	$128	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.32%

Appearance:Solid

Color:Red

Resource Download

COA HPLC HNMR

Product Introduction

Pantoprazole Sodium Hydrate AI Summary

Pantoprazole Sodium Hydrate exhibits a diverse range of bioactivities. It inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) with a potency of 33,498.3 nM and blocks Ebola virus entry with AC50 values between 0.2818 µM and 14,125.4 nM across various assays. The compound also demonstrates the inhibition of Trichomonas vaginalis uridine nucleoside ribohydrolase with an IC50 of 14,500.0 nM, using 5-fluorouridine as a substrate. Moreover, it shows substantial protein binding in human serum (>98.0%) and undergoes significant drug uptake in lactating Sprague-Dawley rat milk and serum. Pantoprazole Sodium Hydrate displays a pKa of 3.9 and an efflux ratio of permeability at 25 µM in MDCK cells, with varied clearance rates and unbound fractions in different rat model matrices. Additionally, it exhibits antiviral activity against SARS-CoV-2, including inhibition of cell viability in Vero E6 cells (inhibition index of 0.7566), cytotoxicity reduction in Caco-2 cells (2.84% inhibition at 10 µM), and a 94.78% inhibition rate of the SARS-CoV-2 3CL-Pro protease at 20 µM. Further, it offers modest antifungal and antibacterial activities against various pathogens, including a 43.3% inhibition of Pseudomonas aeruginosa and 25.84% inhibition of Acinetobacter baumannii..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.
Synonyms	SKF96022 sodium hydrate, SKF96022 (sodium hydrate), BY1023 (sodium hydrate)

Chemical Properties

Molecular Weight	432.37
Formula	C₁₆H₁₄F₂N₃NaO₄S·3/2H₂O
Cas No.	164579-32-2
Smiles	O.[Na+].COc1ccnc(CS(=O)c2nc3cc(OC(F)F)ccc3[n-]2)c1OC
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 4.37 mg/mL (10.11 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.31 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3128 mL	11.5642 mL	23.1283 mL	115.6417 mL
5 mM	0.4626 mL	2.3128 mL	4.6257 mL	23.1283 mL
10 mM	0.2313 mL	1.1564 mL	2.3128 mL	11.5642 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc