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Apoptosis

Apoptosis is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, DNA fragmentation, and mRNA decay.

  • Verteporfin
    T3112129497-78-5
    Verteporfin (BPD-MA) is a YAP inhibitor that inhibits YAP-TEAD interactions. Verteporfin is also a photosensitizer used in photodynamic therapy. Verteporfin also induces apoptosis and inhibits autophagy.
    • $34
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • VTP50469
    T133362169916-18-9
    VTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity.
    • $177
    In Stock
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    TargetMol | Inhibitor Hot
  • Omaveloxolone
    T69191474034-05-3
    Omaveloxolone (RTA-408) (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.
    • $38
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    TargetMol | Inhibitor Hot
  • Niraparib
    T32311038915-60-4
    Niraparib (MK-4827) is a PARP inhibitor that selectively inhibits PARP1 and PARP2 (IC50=3.8/2.1 nM). Niraparib has antitumor activity, inhibits DNA damage repair, and induces apoptosis.
    • $55
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Erdafitinib
    T37261346242-81-6
    Erdafitinib (JNJ-42756493) is a quinoxaline derivative compound, acts on FGFR1/2/3/4.
    • $39
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Inavolisib
    T153752060571-02-8
    Inavolisib (GDC-0077) is an orally available and selective inhibitor of PI3Kα (IC50=0.038 nM). Inavolisib is more selective for mutant versus wild-type PI3Kα. Inavolisib exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3.
    • $80
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    TargetMol | Inhibitor Hot
  • Dinaciclib
    T1912779353-01-4
    Dinaciclib (SCH 727965) is a CDK inhibitor that selectively inhibits CDK1, CDK2, CDK5, and CDK9 (IC50 = 3/1/1/4 nM). Dinaciclib has potential antitumor activity and inhibits the incorporation of thoracic glycan (dThd) DNA.
    • $47
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Pexidartinib
    T21151029044-16-3
    Pexidartinib (PLX-3397) is a capsule formulation containing a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity.
    • $40
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Onvansertib
    T62471034616-18-6
    Onvansertib (NMS-1286937), an oral, specific Polo-like Kinase 1 (PLK1) inhibitor, is with IC50 of 2 nM. The specificity of NMS-P937 forPLK1 is 5000-fold higher over PLK2/PLK3.
    • $39
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Sorafenib
    T0093L284461-73-0
    Sorafenib (Bay 43-9006) is a multikinase inhibitor that inhibits Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, FLT3, c-Kit, and others (IC50=6/22/90/15/20/20/57/58 nM) with oral activity. Sorafenib has antitumor activity and can induce autophagy and apoptosis as well as agonistic ferroptosis.
    • $34
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Y-27632 dihydrochloride
    T1725129830-38-2
    Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells.
    • $39
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Romidepsin
    T6006128517-07-7
    Romidepsin (FR 901228) is an HDAC inhibitor that inhibits HDAC1/2/4/6 (IC50=36/47/510/1400 nM). Romidepsin has antitumor activity and can be used for the treatment of peripheral T-cell lymphoma and cutaneous T-cell lymphoma.
    • $98
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • MK-2206 dihydrochloride
    T19521032350-13-2
    MK-2206 dihydrochloride (MK-2206 2HCl) is a variant Akt inhibitor that inhibits Akt1, Akt2, and Akt3 (IC50=8/12/65 nM) with orally active, highly potent and selective potency. MK-2206 dihydrochloride exhibits antitumor activity.
    • $30
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Cl-amidine hydrochloride
    T10831L1373232-26-8
    Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor (IC50: 5.9 μM for PAD4). Cl-amidine hydrochloride induces apoptosis in cancer cells and it also induces microRNA (miR)-16 in vitro causing cell cycle arrest. Cl-Amidine hydrochloride prevents histone 3 citrullination and neutrophil extracellular trap formation. It improves survival in a murine sepsis model.
    • $97
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • physalin F
    T871657423-71-9
    Physalin F is a natural blocker of CaV2.3 (R-type) and CaV2.2 (N-type) voltage-gated calcium channels.It is a secosteroid with potent anti-inflammatory and immunomodulatory activities. Physalin F induces apoptosis of PBMC, decreasing the spontaneous proliferation and cytokine production caused by Human T-lymphotropic virus type 1 (HTLV-1) infection
    • $45
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    TargetMol | Inhibitor Hot
  • Luminespib
    T1989747412-49-3
    Luminespib (VER-52296) is a new-type inhibitor of HSP90 (IC50s: 7.8/21 nM for HSP90α/β in cell free assay).
    • $52
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Tamoxifen
    T690610540-29-1
    • $39
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    TargetMol | Inhibitor Hot
  • Mdivi-1
    T1907338967-87-6
    Mdivi-1 (Mitochondrial division inhibitor 1) is a mitochondrial division inhibitor that inhibits DRP1 and Dynamin I (IC50=1-10 μM). Mdivi-1 inhibits mitochondrial autophagy.
    • $39
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Bortezomib
    T2399179324-69-7
    Bortezomib (LDP 341) is a 20S proteasome inhibitor (Ki=0.6 nM) that is reversible and selective. Bortezomib has antitumor activity and inhibits NF-κB, which can disrupt the cell cycle and induce apoptosis.
    • $48
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Fedratinib
    T1995936091-26-8
    Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.
    • $45
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Y-27632
    T1870146986-50-7
    Y-27632 (Y-27632) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells.
    • $39
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Notoginsenoside R1
    T296180418-24-2
    Notoginsenoside R1 (Sanchinoside R1) has been shown to exhibit antioxidant, antiapoptotic, anti-inflammatory, and immune-stimulatory properties.
    • $63
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    TargetMol | Inhibitor Hot
  • ICG-001
    T6113780757-88-2
    ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300.
    • $30
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Decitabine
    T15082353-33-5
    Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity. Decitabine has antitumor activity and antimetabolic activity. Decitabine induces cell cycle arrest and apoptosis.
    • $30
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Anisomycin
    T675822862-76-6
    Anisomycin (NSC-76712) is an antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.
    • $46
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Temozolomide
    T117885622-93-1
    Temozolomide (TMZ) is a DNA alkylating agent with blood-brain barrier permeability and oral activity. Temozolomide has antitumor activity and antiangiogenic activity, and also induces apoptosis and autophagy. Temozolomide is stable under acidic conditions and hydrolyzes under neutral or slightly alkaline conditions.
    • $42
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Mezigdomide
    T107032259648-80-9In house
    Mezigdomide (CC-92480) is a potent, novel, selective and active cereblon E3 ubiquitin ligase modulator (CELMoD) that often acts as a molecular glue. Mezigdomide has antimyeloma activity.
    • $118
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    TargetMol | Inhibitor Hot
  • MPTP hydrochloride
    T408123007-85-4
    MPTP hydrochloride is a precursor of MPP+, a dopamine neurotoxin with blood-brain barrier permeability. MPTP hydrochloride is toxic to dopaminergic neurons, which can lead to Parkinson's disease, and is widely used in the construction of animal models of Parkinson's disease.
    • $30
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    TargetMol | Inhibitor Hot
  • Etomoxir sodium salt
    T4535828934-41-4
    Etomoxir sodium salt ((R)-Etomoxir sodium salt) is a carnitine palmitoyltransferase 1a (CPT-1a) inhibitor that blocks fatty acid synthesis. Etomoxir sodium salt has antitumor activity.
    • $55
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Hypericin
    T6S0923548-04-9
    1. Hypericin (Cyclosan) has antineoplastic activity. 2. Hypericin has antibiotic and antiviral activities. 3. Hypericin has antidepressive activity through inhibiting monoamine oxidase enzyme. 4. Hypericin inhibits RANKL-mediated osteoclastogenesis via affecting ERK signalling in vitro and suppresses wear particle-induced osteolysis in vivo.
    • $52
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    TargetMol | Inhibitor Hot
  • Doxorubicin hydrochloride
    T102025316-40-9
    Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM). Doxorubicin hydrochloride exhibits cytotoxicity and antitumor activity. Doxorubicin hydrochloride reduces the phosphorylation of AMPK and its downstream target protein acetyl coenzyme A carboxylase, and induces apoptosis and autophagy.
    • $34
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Ruxolitinib
    T1829941678-49-5
    Ruxolitinib (INCB018424) is a JAK1/2 inhibitor (IC50=3.3/2.8 nM) that is potent and selective. Rixolitinib exhibits antitumor activity and induces autophagy and apoptosis.
    • $53
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Bafilomycin A1
    T674088899-55-2
    Bafilomycin A1 belongs to the macrolide class of antibiotics and is a V-ATPase inhibitor (IC50=0.44 nM) that is specific and reversible. Bafilomycin A1 is an inhibitor of the late phase of autophagy, blocking the fusion of autophagosomes with lysosomes. Bafilomycin A1 also induces apoptosis.
    • $287
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • MG-132
    T2154133407-82-6
    MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor (IC50=100 nM) that is cell-permeable and reversible. MG-132 acts as an autophagy activator and also induces apoptosis.
    • $40
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • TM5441
    T42541190221-43-2
    TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor 1 (PAI-1).
    • $34
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • PROCYANIDIN C1
    TN210337064-30-5
    Procyanidin C1 is a natural product, with anti-inflammatory effects, and induces apoptosis.
    • $72
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Gemcitabine
    T025195058-81-4
    Gemcitabine (LY188011) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. Gemcitabine induces autophagy and apoptosis.
    • $34
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Caudatin
    T315038395-02-7
    Caudatin is one of the species of C-21 steroidal glycosides mainly isolated from the root of Cynanchum bungei Decne and exhibits potent anticancer activities.
    • $84
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    TargetMol | Inhibitor Hot
  • Cabozantinib
    T2586849217-68-1
    Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM). Cabozantinib exhibits both antitumor and antiangiogenic activity.
    • $39
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • TAS6417
    T169961661854-97-2
    TAS6417 is an EGFR inhibitor and is an efficacious drug candidate for patients with NSCLC (IC50: ranging from 1.1-8.0 nM).
    • $89
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Alantolactone
    T2896546-43-0
    Alantolactone (Inula camphor)(Alant camphor), a sesquiterpene lactone, has potential activity against triple-negative breast Y MDA-MB-231 cells by suppressing the signal transducer and activator of transcription 3 (STAT3) signaling pathway.
    • $50
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • LY294002
    T2008154447-36-6
    LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM). LY294002 is also an inhibitor of DNA-PK (IC50=1.4 μM) and an inhibitor of CK2 (IC50=98 nM). LY294002 activates apoptosis and autophagy.
    • $34
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Elesclomol
    T6170488832-69-5
    Elesclomol (STA-4783) is an oxidative stress inducer and a highly lipophilic copper ion carrier. Elesclomol induces apoptosis in tumor cells and is used in copper death related studies. Elesclomol also inhibits FDX1-mediated Fe-S cluster biosynthesis.
    • $34
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • STM2457
    T90602499663-01-1
    STM2457 is an inhibitor of the RNA methyltransferase METTL3 (IC50=16.9 nM) with selective and oral activity.STM2457 can be used in acute myeloid leukemia (AML) studies.
    • $101
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Urolithin A
    T71741143-70-0
    Urolithin A is a secondary metabolite of ellagic acid, a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.
    • $42
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Quizartinib
    T2066950769-58-1
    Quizartinib (AC220) is an inhibitor of FLT3 (Kd: 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.
    • $53
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • CSN5i-3
    T108952375740-98-8In house
    CSN5i-3 is a novel potent oral and selective CSN5/Jab1 inhibitor that inhibits CSN-catalyzed Cul1 deneddylation with an IC50 value of 5.8 nM.CSN5i-3 exhibits anticancer activity, inhibits cell proliferation and induces apoptosis in human breast cancer cells.
    • $378
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    TargetMol | Inhibitor Hot
  • DAPT
    T6202208255-80-5
    DAPT (LY-374973) is a γ-secretase inhibitor that inhibits total Aβ and Aβ42 (IC50=115/200 nM) and is orally active. DAPT is also a Notch inhibitor. DAPT induces cell differentiation, autophagy and apoptosis.
    • $53
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Butein
    T6427487-52-5
    Butein (2’,3,4,4’-tetrahydroxy Chalcone), a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, and also can inhibit EGFR.
    • $36
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Atezolizumab
    T99021380723-44-3
    Atezolizumab (anti-PD-L1) is a fully humanized IgG1 monoclonal antibody that blocks the interaction of PD-L1 with both PD-1 and B7.1 but not the interaction of PD-L2 with PD-1.
    • $229
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    TargetMol | Inhibitor Hot