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Atuliflapon
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Catalog No. T9023Cas No. 2041075-86-7
Alias AZD5718
Atuliflapon (AZD5718) is a novel 5-Lipoxygenase Activating Protein(FLAP) inhibitor for Treatment of Coronary Artery Disease.
Atuliflapon
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Purity: 99.28%
Catalog No. T9023Alias AZD5718Cas No. 2041075-86-7
Atuliflapon (AZD5718) is a novel 5-Lipoxygenase Activating Protein(FLAP) inhibitor for Treatment of Coronary Artery Disease.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $44 | In Stock | In Stock | |
| 5 mg | $98 | In Stock | In Stock | |
| 10 mg | $158 | In Stock | In Stock | |
| 25 mg | $268 | In Stock | In Stock | |
| 50 mg | $371 | In Stock | In Stock | |
| 100 mg | $476 | In Stock | In Stock | |
| 200 mg | $666 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $107 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.28%
Appearance:Solid
Color:White
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Product Introduction
Atuliflapon AI Summary
Atuliflapon exhibits promising bioactivities with potential therapeutic applications, particularly in anti-inflammatory treatments. It demonstrates high inhibition potential against FLAP activity in human systems, with IC50 values of 6.3 nM and fIC50 values of 2.0 nM. In rat systems, it shows moderate inhibition of Mrp2 and BSEP with IC50 values of 74,000.0 nM. The compound has good oral bioavailability and clearance rates in both rats and Beagle dogs, indicating effective systemic uptake and metabolism. It also displays low cytotoxicity in human THP1 and HepG2 cells, with IC50 values exceeding 250,000.0 nM. Selectively inhibiting FLAP activity over COX1 and COX2 in human whole blood, it shows effective ex vivo inhibition in Beagle dogs through reductions in LTB4 and LTE4 levels. Pharmacokinetic properties are favorable, with a half-life of 12.0 hours in humans and 2.1 hours in Beagle dogs post intravenous administration. Additionally, it significantly suppresses calcium ionophore-stimulated LTB4 production at concentrations as low as 15.0 nM in human systems. These findings underscore Atuliflapon's strong anti-inflammatory properties, selective FLAP inhibition, and excellent pharmacokinetic profile, making it a viable candidate for further therapeutic development..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Atuliflapon (AZD5718) is a novel 5-Lipoxygenase Activating Protein(FLAP) inhibitor for Treatment of Coronary Artery Disease. |
| Targets&IC50 | FLAP:2 nM (IC50) |
| Synonyms | AZD5718 |
| Molecular Weight | 446.5 |
| Formula | C24H26N6O3 |
| Cas No. | 2041075-86-7 |
| Smiles | Cc1cc(n[nH]1)-c1ccc(cc1)C(=O)[C@@H]1CCCC[C@H]1C(=O)Nc1cnn2CCNC(=O)c12 |
| Relative Density. | 1.48 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 25 mg/mL (55.99 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.48 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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