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dWIZ-1 ((rac)-dWIZ-1) is a potent WIZ molecular gel degrader that recruits WIZ (ZF7) to the cereblon thereby inducing degradation and thus induction of haemoglobin fetalis (HbF) in erythroblasts, which can be used to study sickle cell disease (SCD).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $195 | In Stock | |
5 mg | $483 | In Stock | |
10 mg | $692 | In Stock | |
25 mg | $1,080 | In Stock |
Description | dWIZ-1 ((rac)-dWIZ-1) is a potent WIZ molecular gel degrader that recruits WIZ (ZF7) to the cereblon thereby inducing degradation and thus induction of haemoglobin fetalis (HbF) in erythroblasts, which can be used to study sickle cell disease (SCD). |
Targets&IC50 | Wiz:0.36 μM (DC₅₀) |
In vitro | dWIZ-1 (Example 2) is a potent inhibitor of Wiz protein, with a DC₅₀ of 0.36 μM. dWIZ-1 is a useful tool compound for investigating genetic blood diseases, including hemoglobin-related disorders like sickle cell anemia and beta-thalassemia[1]. |
Alias | (rac)-dWIZ-1 |
Molecular Weight | 399.48 |
Formula | C22H29N3O4 |
Cas No. | 2879251-63-3 |
Smiles | O=C1C2=CC=C(OC(C)C3N(CC)CCCC3)C=C2CN1C4C(=O)NC(=O)CC4 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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