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CD ProteinsT Cell CD Proteins
T cells are one of the important types of white blood cells of the immune system and play a central role in the adaptive immune response. T cells are born from hematopoietic stem cells, found in the bone marrow. Developing T cells then migrate to the thymus gland to develop (or mature).After migration to the thymus, the precursor cells mature into several distinct types of T cells. T cell differentiation also continues after they have left the thymus.CD4 and CD8 T cells are selected in the thymus, but undergo further differentiation in the periphery to specialized cells which have different functions. Groups of specific, differentiated T cell subtypes have a variety of important functions in controlling and shaping the immune response. One of these functions is immune-mediated cell death, and it is carried out by two major subtypes: CD8+ "killer" (cytotoxic) and CD4+ "helper" T cells. Regulatory T cells are yet another distinct population of T cells that provide the critical mechanism of tolerance, whereby immune cells are able to distinguish invading cells from "self".
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (hFc)
TMPY-02726
RANKL TNFSF11 CD254 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56 kDa and the accession number is AAC40113.1.
- $235
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TLR4 Protein, Human, Recombinant (His)
TMPY-02904
TLR4, also known as TLR-4, is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. TLR4 is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. TLR 4 has also been designated as CD284 (cluster of differentiation 284). It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. TLR4 Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). It acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. It is also involved in LPS-independent inflammatory responses triggered by Ni(2+).
- $588
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CD39 Protein, Human, Recombinant (His)
TMPY-01126
CD39 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 51.8 kDa and the accession number is P49961-1.
- $255
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TLR2 Protein, Human, Recombinant (aa 1-587, His)
TMPY-02794
TLR2 Protein, Human, Recombinant (aa 1-587, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 65.5 kDa and the accession number is O60603-1.
- $386
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CD8 alpha Protein, Human, Recombinant (His), Biotinylated
TMPY-06275
CD8 alpha Protein, Human, Recombinant (His), Biotinylated is expressed in CHO mammalian cells with His tag. The predicted molecular weight is 19 kDa and the accession number is P01732-1.
- $854
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CD8 alpha Protein, Mouse, Recombinant (His), Biotinylated
TMPY-05134
CD8 alpha Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.3 kDa and the accession number is P01731.
- $245
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RANKL/TNFSF11/CD254 Protein, Human, Recombinant
TMPY-03364
RANKL TNFSF11 CD254 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 20.5 kDa and the accession number is AAC51762.1.
- $296
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CD73 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPY-06907
CD73 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 61.04 kDa and the accession number is NP_002517.1.
- $600
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TLR3 Protein, Mouse, Recombinant (His)
TMPY-01396
TLR3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 78.7 kDa and the accession number is Q99MB1.
- $600
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RANKL/TNFSF11/CD254 Protein, Human, Recombinant (aa 63-244, rFc)
TMPY-03527
RANKL TNFSF11 CD254 Protein, Human, Recombinant (aa 63-244, rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 47.9 kDa and the accession number is O14788-2.
- $618
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CD16a Protein, Human, Recombinant (F176V, His)
TMPY-01964
The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also known as CD16a, encodes a transmembrane protein expressed on activated monocytes macrophages, natural killer (NK) cells, and a subset of T cells._x000D_ CD16a FCGR3A is a receptor expressed on NK cells that facilitates antibody dependent cellular cytotoxicity (ADCC) by binding to the Fc portion of various antibodies. CD16a FCGR3A also has a broader function. CD16a FCGR3A is directly involved in the lysis of some virus-infected cells and tumor cells by NK cells, independent of antibody binding. Cross-linking of CD16a FCGR3A on NK cells resulted in increased intracellular Ca2+ levels and a cascade of biochemical events similar to those activated by the T cell receptor. CD16a FCGR3A on human NK cells is a lysis receptor that mediates the direct killing of some virus infected and tumor cells, independent of antibody ligation.
- $386
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CD83 Protein, Human, Recombinant (His)
TMPY-01829
CD83 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.5 kDa and the accession number is Q01151-1.
- $386
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PD-1 Protein, Human, Recombinant (hFc)
TMPY-04898
PD-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.7 kDa and the accession number is A0A0M3M0G7.
- $172
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CD73/5'-Nucleotidase Protein, Mouse, Recombinant (His)
TMPY-01342
CD73 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.4 kDa and the accession number is Q0VEE0.
- $228
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CD40 Ligand Protein, Human, Recombinant (hFc)
TMPY-02022
CD40 Ligand Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.8 kDa and the accession number is P29965.
- $197
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RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli)
TMPJ-00662
CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NFκB, mitogen-activated protein kinases (MAPK), activating protein 1 (AP-1), and nuclear factor of activated T cells (NFATc1), resulting in the formation of multinucleated bone-resorbing osteoclasts. RANKL is widely expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoblast, mammary gland epithelial cells, prostate and pancreas.
- $118
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CD28 Protein, Human/Cynomolgus, Recombinant (His)
TMPJ-00103
CD28 Protein, Human Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 30-40 KDa and the accession number is P10747.
- $56
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Fas Ligand Protein, Human, Recombinant (His)
TMPY-03956
Fas Ligand, also known as FASLG and CD95L, is the ligand for FAS. It is a transmembrane protein which binds to TNFRSF6 FAS. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Fas Ligand may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6 FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Fas Ligand Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 19.3 kDa and the accession number is P48023-1.
- $335
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CD45 Protein, Human, Recombinant (aa 26-577, His)
TMPY-05748
CD45 Protein, Human, Recombinant (aa 26-577, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 62.2 kDa and the accession number is P08575-3.
- $234
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CD8A & CD8B Heterodimer Protein, Human, Recombinant (Flag & His)
TMPY-05669
CD8A & CD8B Heterodimer Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 44.1 kDa and the accession number is NP_001759.3&NP_004922.1.
- $320
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RANKL/TNFSF11/CD254 Protein, Human, Recombinant (His & Flag)
TMPK-00717
Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK system is critical in the formation of mammary epithelia in lactating females and the thermoregulation of the central nervous system. RANKL and RANK are under the tight control of the female sex hormones estradiol and progesterone. RANKL TNFSF11 CD254 Protein, Human, Recombinant (His & Flag) is expressed in HEK293 mammalian cells with N-His-Flag tag. The predicted molecular weight is 22.6 kDa and the accession number is O14788-2.
- $487
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CD38 Protein, Human, Recombinant (His)
TMPY-01023
CD38 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.3 kDa and the accession number is P28907-1.
- $313
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rankl/tnfsf11/cd254 protein, mouse, recombinant (his)
TMPJ-00607
RANKL TNFSF11 CD254 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 30-35 KDa and the accession number is BAA97257.1.
- $118
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CD40 Ligand Protein, Human, Recombinant (Mammalian)
TMPJ-00150
CD40 Ligand Protein, Human, Recombinant (Mammalian) is expressed in HEK293 mammalian cells. The predicted molecular weight is 16-18 KDa and the accession number is P29965.
- $116
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PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPJ-00181
Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28 CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
- $355
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4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (hFc)
TMPJ-00145
Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is a member of the tumor necrosis factor (TNF) receptor family. It can be induced by lymphocyte activation (ILA) and is expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, TNFRSF9 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. As receptor for TNFSF9 4-1BBL, it can activate T cells and the cross-linking of this protein can enhance T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice.
- $110
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RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (Flag & His)
TMPJ-01472
RANKL TNFSF11 CD254 Protein, Mouse, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with N-6xHis-Flag tag. The predicted molecular weight is 23-29 KDa and the accession number is O35235-1.
- $260
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CD28 Protein, Mouse, Recombinant (hFc & His)
TMPJ-00099
T-cell-specific surface glycoprotein CD28, contains an Ig-like V-type domain. CD28 is one of the proteins expressed on T cells that provide co-stimulatory signals, which are required for their activation. It is the receptor for CD80 and CD86. When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. It involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.
- $35
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CD3 epsilon/CD3e Protein, Mouse, Recombinant (His & Myc)
TMPH-02925
CD3 epsilon CD3e Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 17.3 kDa and the accession number is P22646.
- $344
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DPP4/CD26 Protein, Human, Recombinant
TMPY-00779
DPP4 CD26 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 85.4 kDa and the accession number is P27487.
- $451
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CD73/5'-Nucleotidase Protein, Human, Recombinant (His)
TMPY-01851
CD73 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.2 kDa and the accession number is P21589-1.
- $416
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CD40 Ligand Protein, Rat, Recombinant (hFc)
TMPY-03301
CD40 Ligand Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.4 kDa and the accession number is Q9Z2V2.
- $462
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DPP4/CD26 Protein, Mouse, Recombinant (hFc)
TMPY-00221
DPP4 CD26 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 112.9 kDa and the accession number is P28843.
- $221
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CD25/IL2R alpha Protein, Human, Recombinant (His)
TMPY-01103
CD25 IL2R alpha Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.3 kDa and the accession number is P01589.
- $320
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CD16a Protein, Rat, Recombinant (His)
TMPY-02018
CD16a Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.7 kDa and the accession number is A0A8L2QKY4.
- $386
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CD38 Protein, Mouse, Recombinant (hFc)
TMPJ-00190
CD38, also called ADP-ribosyl cyclase, is a Type II integral membrane protein with 301 amino acids in length that belongs to the ADP-ribosyl cyclase family.It synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. And also moonlights as a receptor in cells of the immune system. CD38 is expressed in B and T lymphocytes, osteoclasts, and in cardiac, pancreatic, liver and kidney cells. Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in many types of cells, including neutrophils and pancreatic beta cells.
- $60
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PD-1 Protein, Mouse, Recombinant (hFc)
TMPY-05395
PD-1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.9 kDa and the accession number is Q02242.
- $113
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DPP4/CD26 Protein, Human, Recombinant (His)
TMPY-00122
DPP4 CD26 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86.3 kDa and the accession number is P27487.
- $740
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CD3 epsilon/CD3e 1-27 peptide Protein, Cynomolgus, Recombinant (hFc & Avi)
TMPK-01350
CD3E, is a single-pass type I membrane protein.CD3 (cluster of differentiation 3) T cell co-receptor helps to activate both the cytotoxic T cell (CD8 naive T cells) and also T helper cells (CD4 naive T cells). It consists of a protein complex and is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. CD3 epsilon CD3e 1-27 peptide Protein, Cynomolgus, Recombinant (hFc & Avi) is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The predicted molecular weight is 31.3 kDa and the accession number is Q95LI5.2.
- $581
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CD28 Protein, Canine, Recombinant (His)
TMPK-01176
CD28 is the receptor for CD80 (B7-1) and CD86 (B7-2) proteins.When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. CD28 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 16.7 kDa and the accession number is Q9GKP3.
- $465
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CLEC2D Protein, Human, Recombinant (hFc & Avi)
TMPK-01230
C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Pre-eclampsia and HIV infection have opposing immune responses. The contrasting expression of CLEC2D in HIV infection and pre-eclampsia is demonstrative of the immunosuppressive and pro-inflammatory roles of the respective pathologies. However, this implication may be confounded by highly active anti-retroviral treatment (HAART).
- $534
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CD161 Protein, Human, Recombinant (His)
TMPK-00956
CD161 (NKRP1) is a lectin-like receptor present on NK cells and rare T-cell subsets. We have observed CD161 expression in some cases of T-cell prolymphocytic leukemia (T-PLL) and found it to be useful in follow-up and detection of disease after treatment. CD161 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 19.6 kDa and the accession number is Q12918-1.
- $534
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ILDR2 Protein, Human, Recombinant (His)
TMPJ-00353
ILDR2 is a member of the B7-like family of proteins that regulate T cell activity, is also a known endoplasmic reticulum molecule that regulates lipid homeostasis. The human ILDR2 lumenal domain shares a 99% and 98% homology with the mouse and rat respectively. The human gene encoding ILDR2 is located in a region on Chr1q23–25 that has been associated with type 2 diabetes. ILDR2 plays critical roles in hepatic clearance of lipoproteins and in lipid homeostasis. ILDR2 regulates human dendritic cells (DC2 cells, a subpopulation of polarized DCs that promotes Th2 differentiation). Recent publications reported that ILDR2 displayed negative regulatory functions on human and mouse T cells in various experimental systems. Fusion protein of ILDR2 lumenal domain with an Fc fragment, displays therapeutic effects in collagen-induced arthritis (CIA), a mouse model of rheumatoid arthritis (RA). ILDR2 represents a novel B7-like ligand that exerts negative immune modulation via interaction with a putative counterpart receptor expressed on activated T cells.
- $86
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CD4 Protein, Human, Recombinant (His & Avi)
TMPK-00281
CD4 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 43.6 kDa and the accession number is P01730.
- $313
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CD28 Protein, Human/Cynomolgus/Rhesus macaque, Recombinant (His & Avi), Biotinylated
TMPK-00111
CD28 is the receptor for CD80 (B7-1) and CD86 (B7-2) proteins.When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. CD28 Protein, Human Cynomolgus Rhesus macaque, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 18.2 kDa and the accession number is P10747.
- $814
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OX40/TNFRSF4 Protein, Human, Recombinant (aa 29-216, His & Avi), Biotinylated
TMPK-00168
Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation. OX40 TNFRSF4 Protein, Human, Recombinant (aa 29-216, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 23.2 kDa and the accession number is P43489.
- $814
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CD83 Protein, Human, Recombinant (hFc)
TMPJ-01070
CD83 antigen is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. CD83 is expressed by activated lymphocytes, Langerhans cells and interdigitating reticulum cells. It contains one Ig-like V-type (immunoglobulin-like) domain. , the soluble CD83 has the opposite effect and has an immune inhibitory capacity. Due to its immune inhibitory function, CD83 may play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.
- $116
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OX40/TNFRSF4 Protein, Mouse, Recombinant (His)
TMPJ-00422
OX40 TNFRSF4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 40 KDa and the accession number is P47741.
- $116
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