Contact UsQuotation
Shopping Cart
Remove All
  • TargetMol
    Your shopping cart is currently empty
Proceed to checkoutContinue shopping
TOPBioactivityChemical infoStorage&SolubilityCalculator

(E/Z)-Teriflunomide

Copy Product Info
🥰Excellent
Catalog No. T3044Cas No. 108605-62-5
Alias HMR-1726, Flucyamide, Aubagio, A77 1726

(E/Z)-Teriflunomide (Aubagio), a orally-available Pyrimidine Synthesis Inhibitor, is used to treat relapsing multiple sclerosis.

(E/Z)-Teriflunomide
Other Forms of (E/Z)-Teriflunomide:
TeriflunomideT7534163451-81-8
In Stock
View details

(E/Z)-Teriflunomide

Copy Product Info
🥰Excellent
Purity: 99.76%
Catalog No. T3044Alias HMR-1726, Flucyamide, Aubagio, A77 1726Cas No. 108605-62-5
(E/Z)-Teriflunomide (Aubagio), a orally-available Pyrimidine Synthesis Inhibitor, is used to treat relapsing multiple sclerosis.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 mg$31In StockIn Stock
100 mg$48In StockIn Stock
1 mL x 10 mM (in DMSO)$29In StockIn Stock
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
TargetMol
View More

Batch Information

Select Batch
Purity:99.76%
Color:White
Contact us for more batch information

Resource Download

COA

Product Introduction

Bioactivity
Description
(E/Z)-Teriflunomide (Aubagio), a orally-available Pyrimidine Synthesis Inhibitor, is used to treat relapsing multiple sclerosis.
In vitro
In animal models of demyelinating diseases, Teriflunomide has demonstrated efficacy. For instance, in the black rat model of autoimmune encephalomyelitis, Teriflunomide has shown both preventive and therapeutic effects; similarly, in female Lewis rat models of Experimental Autoimmune Encephalomyelitis (EAE), it has been effective in ameliorating symptoms and reducing disease exacerbation.
In vivo
Teriflunomide acts as a dihydroorotate dehydrogenase inhibitor, thereby inhibiting the de novo synthesis of pyrimidine in rapidly proliferating cells. By suppressing highly proliferative T and B lymphocytes, Teriflunomide effectively reduces the inflammatory response to self-antigens.
SynonymsHMR-1726, Flucyamide, Aubagio, A77 1726
Chemical Properties
Molecular Weight270.21
FormulaC12H9F3N2O2
Cas No.108605-62-5
SmilesN#CC(C(=O)NC1=CC=C(C=C1)C(F)(F)F)=C(O)C
Relative Density.1.424 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 6.25 mg/mL (23.13 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.7008 mL18.5041 mL37.0083 mL185.0413 mL
5 mM0.7402 mL3.7008 mL7.4017 mL37.0083 mL
10 mM0.3701 mL1.8504 mL3.7008 mL18.5041 mL
20 mM0.1850 mL0.9252 mL1.8504 mL9.2521 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TeriflunomideHMR1726HMR 1726Dihydroorotate Dehydrogenase(E/Z)-Teriflunomide
Related Tags: buy (E/Z)-Teriflunomide | purchase (E/Z)-Teriflunomide | (E/Z)-Teriflunomide cost | order (E/Z)-Teriflunomide | (E/Z)-Teriflunomide chemical structure | (E/Z)-Teriflunomide in vivo | (E/Z)-Teriflunomide in vitro | (E/Z)-Teriflunomide formula | (E/Z)-Teriflunomide molecular weight
TargetMol | Logo

Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.