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Hydroxyzine Pamoate

Name: Hydroxyzine Pamoate
Brand: TargetMol
SKU: T0053
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0053Cas No. 10246-75-0

Alias Hydroxyzine embonate, Equipose, Bobsule

Hydroxyzine Pamoate (Bobsule) is a histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.

Hydroxyzine Pamoate

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Purity: 99.49%

Catalog No. T0053Alias Hydroxyzine embonate, Equipose, BobsuleCas No. 10246-75-0

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	In Stock	In Stock
25 mg	$40	In Stock	In Stock
50 mg	$65	In Stock	In Stock
100 mg	$103	In Stock	In Stock
500 mg	$255	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.49%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Hydroxyzine Pamoate AI Summary

Hydroxyzine Pamoate exhibits a broad spectrum of bioactivities, demonstrating potency in inhibiting multiple targets and pathways. The compound is effective in inhibiting hydroxysteroid dehydrogenase 4, tau fibril formation, Cruzain, fructose-1,6-bisphosphate aldolase, histone lysine methyltransferase G9a, Bacillus subtilis Sfp phosphopantetheinyl transferase, Cytochrome P450 3A4, and Menin-MLL interaction, among others. It shows modest antiviral activity against the hepatitis C virus, Marburg virus, vaccinia orthopoxvirus, and SARS-CoV-2, where it inhibits SARS-CoV-2 induced cytotoxicity in both Caco-2 and VERO-6 cells, though with varying degrees of effectiveness. Additionally, Hydroxyzine Pamoate inhibits the SARS-CoV-2 3CL-Pro protease by 29.11% at a concentration of 20µM as determined via a FRET-based peptide substrate assay. Furthermore, Hydroxyzine Pamoate modulates the activity of OATP1B1 and OATP1B3 transporters in sodium fluorescein uptake assays, indicating potential as an OATP transporter modulator. The compound also displays antibacterial properties against multiple bacterial strains including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus (MRSA), with inhibition percentages ranging from 0.33% to 25.25%. It also shows antifungal activity against Candida albicans and Cryptococcus neoformans, albeit with lower inhibition rates. These diverse bioactivities suggest Hydroxyzine Pamoate has significant therapeutic potential across various infectious and non-infectious diseases..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Hydroxyzine Pamoate (Bobsule) is a histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.
Synonyms	Hydroxyzine embonate, Equipose, Bobsule

Chemical Properties

Molecular Weight	763.27
Formula	C₄₄H₄₃ClN₂O₈
Cas No.	10246-75-0
Smiles	OCCOCCN1CCN(CC1)C(c1ccccc1)c1ccc(Cl)cc1.OC(=O)c1cc2ccccc2c(Cc2c(O)c(cc3ccccc23)C(O)=O)c1O
Relative Density.	1.182g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (36.03 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.62 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3102 mL	6.5508 mL	13.1015 mL	65.5076 mL
5 mM	0.2620 mL	1.3102 mL	2.6203 mL	13.1015 mL
10 mM	0.1310 mL	0.6551 mL	1.3102 mL	6.5508 mL
20 mM	0.0655 mL	0.3275 mL	0.6551 mL	3.2754 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc