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CYP19A1/CYP11B2-IN-1

Name: CYP19A1/CYP11B2-IN-1
Brand: TargetMol
SKU: T86150
Price: 74 USD
Availability: InStock
Rating: 5 (10 reviews)

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Synonyms:

Catalog No. T86150 Copy Product Info

Purity: 99.71%

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CYP19A1/CYP11B2-IN-1 is a potent dual inhibitor of aromatase (CYP19A1) and aldosterone synthase (CYP11B2), with IC₅₀ values of 2.3 nM and 29 nM, respectively. CYP19A1/CYP11B2-IN-1 inhibits breast cancer cell proliferation and induces apoptosis (IC₅₀ of 0.26 ± 0.03 μM against MCF-7 cells). CYP19A1/CYP11B2-IN-1 downregulates the PI3K/Akt/mTOR signaling pathway by inhibiting mTOR phosphorylation.

Cas No. 183500-36-9

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Pack Size	Price	USA Stock	Global Stock
1 mg	$74	-	In Stock
5 mg	$179	-	In Stock
10 mg	$289	-	In Stock
25 mg	$579	-	In Stock
50 mg	$953	-	In Stock
100 mg	$1,530	-	In Stock
1 mL x 10 mM (in DMSO)	$198	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.71%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description

In vitro

CYP19A1/CYP11B2-IN-1 (Compound X21) exhibits time- and concentration-dependent inhibitory effects on the proliferation of MCF-7 and MDA-MB-231 cells when administered at concentrations ranging from 0.001 to 100 μM over a 24-hour period. [1]
At a concentration of 700 nM for 24 hours, CYP19A1/CYP11B2-IN-1 significantly inhibits phosphorylation of mTOR in MCF-7 cells, negatively regulating the PI3K/Akt/mTOR axis. [1]
It does not significantly inhibit hERG and Nav1.5 at concentrations of 20-30 μM, indicating a lack of cardiotoxicity. [1]
In cell proliferation assays, the IC50 values were determined as 0.26±0.03 μM for MCF-7 cells and 27.10 ± 5.15 μM for MDA-MB-231 cells, confirming no toxicity to normal cells. [1]
Apoptosis analysis revealed an increase in DNA fragmentation in both cell lines at concentrations of 0.35-1 μM and 10-50 μM after 24 hours of treatment, with higher concentrations (>40 μM) enhancing apoptotic signaling in MDA-MB-231 cells.[1]

Chemical Properties

Molecular Weight	213.24
Formula	C₁₂H₁₁N₃O
Cas No.	183500-36-9
Smiles	N#CC1=CC=C(C=C1)CN2C=NC=C2CO

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (468.96 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6896 mL	23.4478 mL	46.8955 mL	234.4776 mL
5 mM	0.9379 mL	4.6896 mL	9.3791 mL	46.8955 mL
10 mM	0.4690 mL	2.3448 mL	4.6896 mL	23.4478 mL
20 mM	0.2345 mL	1.1724 mL	2.3448 mL	11.7239 mL
50 mM	0.0938 mL	0.4690 mL	0.9379 mL	4.6896 mL
100 mM	0.0469 mL	0.2345 mL	0.4690 mL	2.3448 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: CYP19A1/CYP11B2-IN-1 chemical structure | CYP19A1/CYP11B2-IN-1 in vitro | CYP19A1/CYP11B2-IN-1 formula | CYP19A1/CYP11B2-IN-1 molecular weight