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Dopamine hydrochloride
🥰Excellent
Catalog No. T1644Cas No. 62-31-7
Alias Dopamine HCl, ASL279
Dopamine hydrochloride (ASL279) is a natural catecholamine neurotransmitter that mainly acts on dopamine receptors (D1-5 receptors) (EC50=2.7 nM). Dopamine hydrochloride induces VEGFR2 endocytosis through D2 dopamine receptor and has pro-angiogenic activity.
Dopamine hydrochloride
🥰Excellent
Purity: 99.72%
Catalog No. T1644Alias Dopamine HCl, ASL279Cas No. 62-31-7
Dopamine hydrochloride (ASL279) is a natural catecholamine neurotransmitter that mainly acts on dopamine receptors (D1-5 receptors) (EC50=2.7 nM). Dopamine hydrochloride induces VEGFR2 endocytosis through D2 dopamine receptor and has pro-angiogenic activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 mg | $30 | In Stock | |
| 100 mg | $42 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $30 | In Stock |
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Purity:99.72%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Dopamine hydrochloride (ASL279) is a natural catecholamine neurotransmitter that mainly acts on dopamine receptors (D1-5 receptors) (EC50=2.7 nM). Dopamine hydrochloride induces VEGFR2 endocytosis through D2 dopamine receptor and has pro-angiogenic activity. |
| Targets&IC50 | Prolactin release:60 nM, Amplitude of GABAA IPSCs:3.4 ± 0.8 μM, Arachidonic acid (Release):0.5 nM (CHO cells), Dopamine D1 receptor:55.5 nM (EC50), Excitatory postsynaptic currents:12.8 ± 2.8 μM |
| In vitro | METHODS: CYP3A4/5, CYP2C19 and CYP2C9 were treated with Resmetirom to detect the inhibition of cell growth. RESULTS: The IC50 of ResmetiromCYP3A4/5 and CYP2C19 were both greater than 50 μM, with no growth inhibitory effect. The inhibitory effect on CYP2C9 was relatively weak, and the IC50 was approximately 22 μM. [1] |
| Synonyms | Dopamine HCl, ASL279 |
| Molecular Weight | 189.639 |
| Formula | C8H12ClNO2 |
| Cas No. | 62-31-7 |
| Smiles | Cl.NCCc1ccc(O)c(O)c1 |
| Relative Density. | 1.4 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (290.02 mM), Sonication is recommended.  H2O: 19 mg/mL (100.19 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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