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Dopamine hydrochloride

Name: Dopamine hydrochloride
Brand: TargetMol
SKU: T1644
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1644Cas No. 62-31-7

Alias Dopamine HCl, ASL279

Dopamine hydrochloride (ASL279) is a natural catecholamine neurotransmitter that mainly acts on dopamine receptors (D1-5 receptors) (EC50=2.7 nM). Dopamine hydrochloride induces VEGFR2 endocytosis through D2 dopamine receptor and has pro-angiogenic activity.

Dopamine hydrochloride

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Purity: 99.72%

Catalog No. T1644Alias Dopamine HCl, ASL279Cas No. 62-31-7

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	In Stock	In Stock
100 mg	$42	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.72%

Color:White

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	Dopamine hydrochloride (ASL279) is a natural catecholamine neurotransmitter that mainly acts on dopamine receptors (D1-5 receptors) (EC50=2.7 nM). Dopamine hydrochloride induces VEGFR2 endocytosis through D2 dopamine receptor and has pro-angiogenic activity.
Targets&IC50	Dopamine D1 receptor:55.5 nM (EC50), Prolactin release:60 nM, Amplitude of GABAA IPSCs:3.4 ± 0.8 μM, Arachidonic acid (Release):0.5 nM (CHO cells), Excitatory postsynaptic currents:12.8 ± 2.8 μM
In vitro	METHODS: CYP3A4/5, CYP2C19 and CYP2C9 were treated with Resmetirom to detect the inhibition of cell growth. RESULTS: The IC50 of ResmetiromCYP3A4/5 and CYP2C19 were both greater than 50 μM, with no growth inhibitory effect. The inhibitory effect on CYP2C9 was relatively weak, and the IC50 was approximately 22 μM. [1]
Synonyms	Dopamine HCl, ASL279

Chemical Properties

Molecular Weight	189.64
Formula	C₈H₁₂ClNO₂
Cas No.	62-31-7
Smiles	Cl.NCCc1ccc(O)c(O)c1
Relative Density.	1.4 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (290.02 mM), Sonication is recommended.

H2O: 19 mg/mL (100.19 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.2731 mL	26.3657 mL	52.7315 mL	263.6575 mL
5 mM	1.0546 mL	5.2731 mL	10.5463 mL	52.7315 mL
10 mM	0.5273 mL	2.6366 mL	5.2731 mL	26.3657 mL
20 mM	0.2637 mL	1.3183 mL	2.6366 mL	13.1829 mL
50 mM	0.1055 mL	0.5273 mL	1.0546 mL	5.2731 mL
100 mM	0.0527 mL	0.2637 mL	0.5273 mL	2.6366 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc