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Dopamine hydrochloride

🥰Excellent
Catalog No. T1644Cas No. 62-31-7
Alias Dopamine HCl, ASL279

Dopamine hydrochloride (ASL279) is a natural catecholamine neurotransmitter that mainly acts on dopamine receptors (D1-5 receptors) (EC50=2.7 nM). Dopamine hydrochloride induces VEGFR2 endocytosis through D2 dopamine receptor and has pro-angiogenic activity.

Dopamine hydrochloride

Dopamine hydrochloride

🥰Excellent
Purity: 99.72%
Catalog No. T1644Alias Dopamine HCl, ASL279Cas No. 62-31-7
Dopamine hydrochloride (ASL279) is a natural catecholamine neurotransmitter that mainly acts on dopamine receptors (D1-5 receptors) (EC50=2.7 nM). Dopamine hydrochloride induces VEGFR2 endocytosis through D2 dopamine receptor and has pro-angiogenic activity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 mg$30In StockIn Stock
100 mg$42In StockIn Stock
1 mL x 10 mM (in DMSO)$30In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.72%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
Dopamine hydrochloride (ASL279) is a natural catecholamine neurotransmitter that mainly acts on dopamine receptors (D1-5 receptors) (EC50=2.7 nM). Dopamine hydrochloride induces VEGFR2 endocytosis through D2 dopamine receptor and has pro-angiogenic activity.
Targets&IC50
Excitatory postsynaptic currents:12.8 ± 2.8 μM, Dopamine D1 receptor:55.5 nM (EC50), Amplitude of GABAA IPSCs:3.4 ± 0.8 μM, Prolactin release:60 nM, Arachidonic acid (Release):0.5 nM (CHO cells)
In vitro
METHODS: CYP3A4/5, CYP2C19 and CYP2C9 were treated with Resmetirom to detect the inhibition of cell growth.
RESULTS: The IC50 of ResmetiromCYP3A4/5 and CYP2C19 were both greater than 50 μM, with no growth inhibitory effect. The inhibitory effect on CYP2C9 was relatively weak, and the IC50 was approximately 22 μM. [1]
SynonymsDopamine HCl, ASL279
Chemical Properties
Molecular Weight189.64
FormulaC8H12ClNO2
Cas No.62-31-7
SmilesCl.NCCc1ccc(O)c(O)c1
Relative Density.1.4 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 55.00 mg/mL (290.02 mM), Sonication is recommended.
H2O: 19.00 mg/mL (100.19 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM5.2731 mL26.3657 mL52.7315 mL263.6575 mL
5 mM1.0546 mL5.2731 mL10.5463 mL52.7315 mL
10 mM0.5273 mL2.6366 mL5.2731 mL26.3657 mL
20 mM0.2637 mL1.3183 mL2.6366 mL13.1829 mL
50 mM0.1055 mL0.5273 mL1.0546 mL5.2731 mL
100 mM0.0527 mL0.2637 mL0.5273 mL2.6366 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

proliferationneurotransmitterInhibitorinhibitHUVECsFerroptosisEndogenousMetaboliteEndogenous MetaboliteDopamineReceptorDopamine ReceptorDopamine HydrochlorideDopamine hydrochlorideDopamineDA transportercatecholamineASL-279ASL 2795HTReceptor5HT Receptor5-HT
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