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Anti-LPAR1 Antibody (3T102)
😃Good
Catalog No. TMAH-00702
Alias Lysophosphatidic acid receptor Edg-2, Lysophosphatidic acid receptor 1, LPAR 1, LPA-1, LPA1, LPA receptor 1, EDG2
Anti-LPAR1 Antibody (3T102) is an antibody targeting LPAR1. Anti-LPAR1 Antibody (3T102) can be used in ELISA, WB.
Anti-LPAR1 Antibody (3T102)
Anti-LPAR1 Antibody (3T102)
😃Good
Catalog No. TMAH-00702Alias Lysophosphatidic acid receptor Edg-2, Lysophosphatidic acid receptor 1, LPAR 1, LPA-1, LPA1, LPA receptor 1, EDG2
Anti-LPAR1 Antibody (3T102) is an antibody targeting LPAR1. Anti-LPAR1 Antibody (3T102) can be used in ELISA, WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $207 | 7-10 days | |
| 100 μL | $347 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Monoclonal Application: ELISA, WB Reactivity: Human |
| Alias | Lysophosphatidic acid receptor Edg-2, Lysophosphatidic acid receptor 1, LPAR 1, LPA-1, LPA1, LPA receptor 1, EDG2 |
| Ig Type | Rabbit IgG |
| Clone | 3T102 |
| Reactivity | Human |
| Verified Activity | Western Blot -Positive WB detected in: Hela whole cell lysate, A375 whole cell lysate -All lanes: EDG2 antibody at 1:1000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 42, 42 kDa -Observed band size: 42 kDa |
| Application | ELISA, WB |
| Recommended Dose | WB:1:500-1:5000. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cell surface. Cell membrane; Multi-pass membrane protein. Endosome. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Receptor for lysophosphatidic acid (LPA). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels. Signaling triggers an increase of cytoplasmic Ca(2+) levels. Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate. Signaling mediates activation of down-stream MAP kinases. Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction. Promotes the activation of Rho and the formation of actin stress fibers. Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1. Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding. Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human EDG2 |
| Antigen Species | Human |
| Gene ID | 1902 |
| Uniprot ID | |
| Biology Area | Cancer, Cardiovascular, Metabolism, Signal transduction |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
Sci Citations
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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