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TH5487

Name: TH5487
Brand: TargetMol
SKU: T8119
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8119Cas No. 2304947-71-3

TH5487 is an potent inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1)( IC50 of 342 nM)

TH5487

🥰Excellent

Purity: 98.73%

Catalog No. T8119Cas No. 2304947-71-3

TH5487 is an potent inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1)( IC50 of 342 nM)

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$40	In Stock	In Stock
2 mg	$57	In Stock	In Stock
5 mg	$95	In Stock	In Stock
10 mg	$163	In Stock	In Stock
25 mg	$319	In Stock	In Stock
50 mg	$578	In Stock	In Stock
100 mg	$833	In Stock	In Stock
500 mg	$1,690	-	In Stock
1 mL x 10 mM (in DMSO)	$113	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:98.73%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	TH5487 is an potent inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1)( IC50 of 342 nM)
Targets&IC50	OGG1:342 nM
In vitro	TH5487 Inhibited proinflammatory gene expression dose-dependently.
In vivo	TH5487 (prophylactic intraperitoneally injection; 8-30 mg/kg; 1-9 hours) decreases TNFα or LPS induced the robust recruitment of neutrophils to the airways, and reduces the pulmonary neutrophil count in a time-dependent manner. TH5487 InterruptedTNFα-induced ongoing inflammatory processes.
Cell Research	Cell Line:Murine airway epithelial cell line (MLE 12); Diploid human small-airway epithelial cell (hSAECs). Concentration:5 μM. Incubation Time:1 hour
Animal Research	Animal Model:Eightweek-old female and male BALB/c mice. Dosage:8 mg/kg, 15 mg/kg, 30 mg/kg. Administration:Prophylactic intraperitoneally injection; 8-30 mg/kg; 1-9 hours

Chemical Properties

Molecular Weight	541.18
Formula	C₁₉H₁₈BrIN₄O₂
Cas No.	2304947-71-3
Smiles	Brc1cccc2n(C3CCN(CC3)C(=O)Nc3ccc(I)cc3)c(=O)[nH]c12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (83.15 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.7 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8478 mL	9.2391 mL	18.4781 mL	92.3907 mL
5 mM	0.3696 mL	1.8478 mL	3.6956 mL	18.4781 mL
10 mM	0.1848 mL	0.9239 mL	1.8478 mL	9.2391 mL
20 mM	0.0924 mL	0.4620 mL	0.9239 mL	4.6195 mL
50 mM	0.0370 mL	0.1848 mL	0.3696 mL	1.8478 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc