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Anti-IL-1RAP/IL-1RAcP Antibody (6Q78) (Synonyms: interleukin 1 receptor accessory protein, IL-1RAcP, IL1R3, C...)
Catalog No. TMAH-00619 Copy Product Info
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Anti-IL-1RAP/IL-1RAcP Antibody (6Q78) is an antibody targeting IL-1RAP/IL-1RAcP. Anti-IL-1RAP/IL-1RAcP Antibody (6Q78) can be used in ELISA.
Anti-IL-1RAP/IL-1RAcP Antibody (6Q78)
Copy Product Info🥰Excellent
Catalog No. TMAH-00619
Synonyms interleukin 1 receptor accessory protein, IL-1RAcP, IL1R3, C3orf13
Anti-IL-1RAP/IL-1RAcP Antibody (6Q78) is an antibody targeting IL-1RAP/IL-1RAcP. Anti-IL-1RAP/IL-1RAcP Antibody (6Q78) can be used in ELISA.
Anti-IL-1RAP/IL-1RAcP Antibody
(6Q78)
(6Q78)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $208 | 7-10 days | 7-10 days | |
| 100 μL | $348 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-IL-1RAP/IL-1RAcP Antibody (6Q78) is an antibody targeting IL-1RAP/IL-1RAcP. Anti-IL-1RAP/IL-1RAcP Antibody (6Q78) can be used in ELISA. |
| Synonyms | interleukin 1 receptor accessory protein, IL-1RAcP, IL1R3, C3orf13 |
| Ig Type | hIgG1 |
| Clone | 6Q78 |
| Reactivity | Human, Macaca fascicularis |
| Verified Activity | 1. The Binding Activity of Macaca fascicularis IL1RAP with Anti-IL1RAP recombinant antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis IL1RAP at 2 μg/mL can bind Anti-IL1RAP recombinant antibody. The EC50 is 0.9099-1.181 ng/mL. 2. The Binding Activity of Human IL1RAP with Anti-IL1RAP recombinant antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized Human IL1RAP at 2 μg/mL can bind Anti-IL1RAP recombinant antibody. The EC50 is 0.9667-1.477 ng/mL. |
| Application | |
| Recommended Dose | ELISA:1:5000-1:50000. |
| Antibody Type | Monoclonal |
| Subcellular Localization | [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted. |
| Tissue Specificity | Detected in liver, skin, placenta, thymus and lung. Isoform 4 is predominantly expressed in brain. Overexpressed on candidate chronic myeloid leukemia (CML) stem cells, hematopoietic stem cells and mononuclear cells of patients with acute myeloid leukemia |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Research Background | Coreceptor for IL1RL2 in the IL-36 signaling system. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD. May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable). Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling. Unable to mediate canonical IL-1 signaling. Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human IL1RAP Protein |
| Antigen Species | Human |
| Gene Name | IL1RAP |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Cardiovascular, Immunology |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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