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Pyromeconic acid

Name: Pyromeconic acid
Brand: TargetMol
SKU: TL0015
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TL0015Cas No. 496-63-9

Alias 3-hydroxy-4H-pyran-4-one

Pyromeconic acid (3-hydroxy-4H-pyran-4-one) and derivatives thereof are potent inhibitors of endonuclease

Pyromeconic acid

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Purity: 99.35%

Catalog No. TL0015Alias 3-hydroxy-4H-pyran-4-oneCas No. 496-63-9

Pyromeconic acid (3-hydroxy-4H-pyran-4-one) and derivatives thereof are potent inhibitors of endonuclease

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$36	In Stock	In Stock
100 mg	$56	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.35%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Pyromeconic acid AI Summary

Pyromeconic acid exhibits significant chemical and biological properties. It has a pKa2 value of 8.7 and a Log beta3 value of 28.4, indicative of a high cumulative stability constant and suggesting robust chelating potential. The compound forms complexes with Iron-III, gallium-III, and Indium-III, as evidenced by different distribution coefficients and mean log D values across various assays. Biologically, Pyromeconic acid demonstrates broad inhibitory effects on enzymes and proteins such as MMPs (MMP1, MMP2, MMP3, MMP8, MMP9), 5-lipoxygenase, anthrax lethal factor, mushroom tyrosinase, and mouse iNOS, including a notable 81.0% inhibition of 5-lipoxygenase, indicating its potential anti-inflammatory properties. It also inhibits the Influenza A (H1N1) PA endonuclease, with IC50 values of 22500.0 nM and 25118.86 nM, showcasing its antiviral potential. Additionally, Pyromeconic acid shows bioactivity as an inhibitor of recombinant human QC, with an IC50 value of 232,000.0 nM. These properties position Pyromeconic acid as a candidate for further therapeutic research and development..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Pyromeconic acid (3-hydroxy-4H-pyran-4-one) and derivatives thereof are potent inhibitors of endonuclease
Synonyms	3-hydroxy-4H-pyran-4-one

Chemical Properties

Molecular Weight	112.08
Formula	C₅H₄O₃
Cas No.	496-63-9
Smiles	OC1=COC=CC1=O
Relative Density.	1.483 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (401.5 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (17.84 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	8.9222 mL	44.6110 mL	89.2220 mL	446.1099 mL
5 mM	1.7844 mL	8.9222 mL	17.8444 mL	89.2220 mL
10 mM	0.8922 mL	4.4611 mL	8.9222 mL	44.6110 mL
20 mM	0.4461 mL	2.2305 mL	4.4611 mL	22.3055 mL
50 mM	0.1784 mL	0.8922 mL	1.7844 mL	8.9222 mL
100 mM	0.0892 mL	0.4461 mL	0.8922 mL	4.4611 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc