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Pyromeconic acid
(Synonyms: 3-hydroxy-4H-pyran-4-one) Copy Product Info
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Synonyms: 3-hydroxy-4H-pyran-4-one
Catalog No. TL0015 Copy Product Info
Purity: 99.35%
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Pyromeconic acid (3-hydroxy-4H-pyran-4-one) is a naturally occurring gamma-pyrone derivative isolated from Erigeron annuus, characterized by its metal-chelating and redox-active properties. In neuroprotective studies, its optimized derivatives demonstrate potent inhibition of Aβ₁₋₄₂ self-aggregation (IC₅₀ = 11.15 μM) and promotion of fibril disaggregation (IC₅₀ = 6.87 μM), with enhanced activity against Cu²⁺-induced aggregation (IC₅₀ = 3.69 μM). The compound exhibits robust antioxidant capacity (oxygen radical absorbance capacity of 2.65 Trolox equivalents) and moderate anti-inflammatory activity, with pharmacokinetic data showing selective accumulation in the hippocampus (hippocampus-to-plasma ratio up to 7.12). These properties make pyromeconic acid a valuable scaffold for research into oxidative stress, metal ion dyshomeostasis, and protein aggregation.
Cas No. 496-63-9
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 100 mg | $34 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.35%
Appearance:Solid
Color:Yellow
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Product Information
Pyromeconic acid AI Summary
Pyromeconic acid exhibits significant chemical and biological properties. It has a pKa2 value of 8.7 and a Log beta3 value of 28.4, indicative of a high cumulative stability constant and suggesting robust chelating potential. The compound forms complexes with Iron-III, gallium-III, and Indium-III, as evidenced by different distribution coefficients and mean log D values across various assays. Biologically, Pyromeconic acid demonstrates broad inhibitory effects on enzymes and proteins such as MMPs (MMP1, MMP2, MMP3, MMP8, MMP9), 5-lipoxygenase, anthrax lethal factor, mushroom tyrosinase, and mouse iNOS, including a notable 81.0% inhibition of 5-lipoxygenase, indicating its potential anti-inflammatory properties. It also inhibits the Influenza A (H1N1) PA endonuclease, with IC50 values of 22500.0 nM and 25118.86 nM, showcasing its antiviral potential. Additionally, Pyromeconic acid shows bioactivity as an inhibitor of recombinant human QC, with an IC50 value of 232,000.0 nM. These properties position Pyromeconic acid as a candidate for further therapeutic research and development..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Pyromeconic acid (3-hydroxy-4H-pyran-4-one) is a naturally occurring gamma-pyrone derivative isolated from Erigeron annuus, characterized by its metal-chelating and redox-active properties. In neuroprotective studies, its optimized derivatives demonstrate potent inhibition of Aβ₁₋₄₂ self-aggregation (IC₅₀ = 11.15 μM) and promotion of fibril disaggregation (IC₅₀ = 6.87 μM), with enhanced activity against Cu²⁺-induced aggregation (IC₅₀ = 3.69 μM). The compound exhibits robust antioxidant capacity (oxygen radical absorbance capacity of 2.65 Trolox equivalents) and moderate anti-inflammatory activity, with pharmacokinetic data showing selective accumulation in the hippocampus (hippocampus-to-plasma ratio up to 7.12). These properties make pyromeconic acid a valuable scaffold for research into oxidative stress, metal ion dyshomeostasis, and protein aggregation. |
| Synonyms | 3-hydroxy-4H-pyran-4-one |
| Molecular Weight | 112.08 |
| Formula | C5H4O3 |
| Cas No. | 496-63-9 |
| Smiles | OC1=COC=CC1=O |
| Relative Density. | 1.483 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (401.5 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (17.84 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Product Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Pyromeconic acid chemical structure | Pyromeconic acid formula | Pyromeconic acid molecular weight
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