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Olanzapine

Name: Olanzapine
Brand: TargetMol
SKU: T1567
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1567Cas No. 132539-06-1

Alias LY170053

Olanzapine (LY170053) is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.

Olanzapine

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Purity: 99.88%

Catalog No. T1567Alias LY170053Cas No. 132539-06-1

Olanzapine (LY170053) is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	In Stock	In Stock
50 mg	$39	In Stock	In Stock
100 mg	$55	In Stock	In Stock
500 mg	$123	In Stock	In Stock
1 g	$179	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.88%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Olanzapine (LY170053) is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.
Targets&IC50	α1-adrenoceptor:19 nM (Ki), 5-HT1 receptor:7 nM (Ki), 5-HT2C receptor:11 nM (Ki), Muscarinic M1-5 Receptor:1.9-25 nM (Ki), 5-HT3 receptor:57 nM (Ki), 5-HT6 receptor:5 nM (Ki), 5-HT2A receptor:4 nM (Ki)
In vitro	Olanzapine is a potent antagonist of DA and 5-HT receptors, which elevates the extracellular levels of DA metabolites, such as DOPAC, and the DA metabolite 3-methoxytyramine, in the prefrontal cortex, nucleus accumbens, and striatum of rats. Subcutaneous injections of Olanzapine (0.5-10 mg/kg) increase the levels of dopamine (DA) and norepinephrine (NE) in these regions in a dose-dependent manner. Additionally, Olanzapine significantly inhibits insulin, leading to the onset of obesity.
In vivo	Olanzapine interacts with several key receptors associated with schizophrenia, demonstrating nanomolar affinity for dopamine, serotonin, alpha-1 adrenergic, and cholinergic receptors. Specifically, Olanzapine selectively targets striatal dopamine in the limbic and cortical regions of the brain, exhibiting no selectivity towards dopamine receptor subtypes.
Synonyms	LY170053

Chemical Properties

Molecular Weight	312.43
Formula	C₁₇H₂₀N₄S
Cas No.	132539-06-1
Smiles	CN1CCN(CC1)C1=NC2=C(NC3=C1C=C(C)S3)C=CC=C2
Relative Density.	1.32 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 240 mg/mL (768.17 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (16 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2007 mL	16.0036 mL	32.0072 mL	160.0358 mL
5 mM	0.6401 mL	3.2007 mL	6.4014 mL	32.0072 mL
10 mM	0.3201 mL	1.6004 mL	3.2007 mL	16.0036 mL
20 mM	0.1600 mL	0.8002 mL	1.6004 mL	8.0018 mL
50 mM	0.0640 mL	0.3201 mL	0.6401 mL	3.2007 mL
100 mM	0.0320 mL	0.1600 mL	0.3201 mL	1.6004 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Olanzapine

Olanzapine

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