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Acivicin (Synonyms: U-42126, U42126, U 42126, AT-125, AT125, AT 125)

Name: Acivicin
Brand: TargetMol
SKU: T14114
Rating: 4.5 (1 reviews)

Catalog No. T14114 Copy Product Info

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Acivicin (AT-125), a chlorinated amino acid antibiotic produced by Streptomyces porcineus, is a γ-glutamyl transpeptidase (GGT) inhibitor that crosses the blood-brain barrier, exhibits anticancer and antiparasitic activity, and is used in the study of visceral leishmaniasis.

Acivicin

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Catalog No. T14114

Synonyms U-42126, U42126, U 42126, AT-125, AT125, AT 125

Cas No. 42228-92-2

Pack Size	Price	USA Stock	Global Stock
1 mg	$178	35 days	35 days
5 mg	$696	35 days	35 days
10 mg	$980	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Acivicin (AT-125), a chlorinated amino acid antibiotic produced by Streptomyces porcineus, is a γ-glutamyl transpeptidase (GGT) inhibitor that crosses the blood-brain barrier, exhibits anticancer and antiparasitic activity, and is used in the study of visceral leishmaniasis.
In vivo	In male pigmented Long-Evans rats weighing between 250 g and 300 g exposed to toluene, Acivicin (5 mg/kg; intraperitoneal injection; twice weekly) was able to reduce urinary γ-GT by 70-78%[3].
Synonyms	U-42126, U42126, U 42126, AT-125, AT125, AT 125

Chemical Properties

Molecular Weight	178.57
Formula	C₅H₇ClN₂O₃
Cas No.	42228-92-2
Smiles	N[C@@H]([C@@H]1CC(Cl)=NO1)C(O)=O
Relative Density.	1.85 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 4 mg/mL (22.4 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	5.6000 mL	28.0002 mL	56.0004 mL	280.0022 mL
5 mM	1.1200 mL	5.6000 mL	11.2001 mL	56.0004 mL
10 mM	0.5600 mL	2.8000 mL	5.6000 mL	28.0002 mL
20 mM	0.2800 mL	1.4000 mL	2.8000 mL	14.0001 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc