Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ZLN 024 hydrochloride is an AMPK allosteric activator and stimulates the inactive α1 subunit truncations α1 (1-394) and α1 (1-335) but not α1 (1-312).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 38.00 | |
5 mg | In stock | $ 62.00 | |
10 mg | In stock | $ 97.00 | |
25 mg | In stock | $ 223.00 | |
50 mg | In stock | $ 415.00 | |
100 mg | In stock | $ 646.00 | |
500 mg | In stock | $ 1,330.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 68.00 |
Description | ZLN 024 hydrochloride is an AMPK allosteric activator and stimulates the inactive α1 subunit truncations α1 (1-394) and α1 (1-335) but not α1 (1-312). |
Targets&IC50 | AMPK α2β2γ1:0.13 μM (EC50), AMPK α1β1γ1:0.42 μM (EC50), AMPK α1β2γ1:1.1 µM (EC50), AMPK α2β1γ1:0.95 μM (EC50) |
In vitro | ZLN 024 hydrochloride increases the activity of α1β1γ1 by 1.5-fold and has an EC50 of 0.42 µM, and it increases the activity of α2β1γ1 by 1.7-fold with an EC50 of 0.95 µM. ZLN 024 hydrochloride also directly activates recombinant AMPK α1β2γ1, by 1.7-fold with an EC50 of 1.1 µM; and AMPK α2β2γ1, by 1.6-fold with an EC50 of 0.13 µM. ZLN 024 hydrochloride directly activates recombinant AMPK α1β1γ1 and its homolog α2β1γ1 in a concentration-dependent manner[1]. |
In vivo | In C57BKS db/db mice, ZLN 024 hydrochloride(15 mg/kg/day; oral) improves glucose tolerance after 4 weeks of treatment. ZLN 024 hydrochloride reduces the fasting blood glucose by 15%. Liver tissue weight, triacylglycerol and the total cholesterol content a |
Molecular Weight | 361.68 |
Formula | C13H14BrClN2OS |
CAS No. | 1883548-91-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (124.42 mM)
H2O: < 0.1 mg/mL (insoluble)
You can also refer to dose conversion for different animals. More
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ZLN 024 hydrochloride 1883548-91-1 Chromatin/Epigenetic PI3K/Akt/mTOR signaling AMPK Inhibitor AMP-activated protein kinase ZLN-024 inhibit ZLN 024 Hydrochloride ZLN-024 Hydrochloride ZLN024 ZLN 024 ZLN024 Hydrochloride inhibitor